A novel tandem process leading to functionalized glutarimides
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The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized. (c) 2005 Elsevier Ltd. All rights reserved.
Кључне речи:synthesis / functionalized or spirobicyclic glutarimides / tandem process
Извор:Tetrahedron Letters, 2005, 46, 15, 2611-2614
- Pergamon-Elsevier Science Ltd, Oxford