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A novel tandem process leading to functionalized glutarimides

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2005
Authors
Popović-Đorđević, Jelena B.
Ivanović, Milovan D.
Kiricojević, Vesna
Article (Published version)
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Abstract
The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized. (c) 2005 Elsevier Ltd. All rights reserved.
Keywords:
synthesis / functionalized or spirobicyclic glutarimides / tandem process
Source:
Tetrahedron Letters, 2005, 46, 15, 2611-2614
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford

DOI: 10.1016/j.tetlet.2005.02.087

ISSN: 0040-4039

WoS: 000228115600019

Scopus: 2-s2.0-15244347524
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/2678
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IHTM

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