A novel tandem process leading to functionalized glutarimides
Abstract
The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized. (c) 2005 Elsevier Ltd. All rights reserved.
Keywords:
synthesis / functionalized or spirobicyclic glutarimides / tandem processSource:
Tetrahedron Letters, 2005, 46, 15, 2611-2614Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
DOI: 10.1016/j.tetlet.2005.02.087
ISSN: 0040-4039