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dc.creatorPantelić, Nebojša Đ.
dc.creatorZmejkovski, Bojana
dc.creatorŽižak, Željko
dc.creatorBanjac, Nebojša R.
dc.creatorBožić, Bojan
dc.creatorStanojković, Tatjana
dc.creatorKaluđerović, Goran N.
dc.date.accessioned2019-03-29T06:19:59Z
dc.date.available2019-03-29T06:19:59Z
dc.date.issued2019
dc.identifier.issn2090-9063
dc.identifier.urihttps://www.hindawi.com/journals/jchem/2019/2905840/
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2639
dc.description.abstractA novel triphenyltin(IV) compound with 1-(4-carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione was synthesized and characterized by IR, NMR spectroscopy, mass spectrometry, and elemental analysis. In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. The results indicate that complex exhibited very high antiproliferative activity against all tested cell lines with IC 50 values in the range of 0.22 to 0.53 µ M. The highest activity organotin(IV) compound expressed against the HeLa cells (IC 50 = 0.22 ± 0.04 µ M). The ligand precursor did not show anticancer activity (IC 50 > 200 µ M). Furthermore, fluorescence microscopy analysis of HeLa cells reveal that organotin(IV) complex induced apoptosis as a mode of cell death, which is consistent with the increase of cells in the sub-G1 phase.en
dc.publisherHindawi
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.relationNational Scholarship for Postdoctoral Studies of the Republic of Serbia (N. Đ. Pantelić)
dc.rightsopenAccess
dc.sourceJournal of Chemistry
dc.sourceJournal of Chemistry
dc.titleDesign and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dioneen
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractКалуђеровић, Горан Н.; Змејковски, Бојана Б.; Пантелић, Небојша Ђ.; Жижак, Жељко; Бањац, Небојша Р.; Божић, Бојан Ђ.; Станојковић, Татјана П.;
dc.citation.spage2905840
dc.citation.rankM22~
dc.identifier.doi10.1155/2019/2905840
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/6221/2905840.pdf
dc.identifier.scopus2-s2.0-85060787696
dc.identifier.wos000457022700001
dc.type.versionpublishedVersion


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