Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione
Authors
Pantelić, Nebojša Đ.
Zmejkovski, Bojana

Žižak, Željko

Banjac, Nebojša R.

Božić, Bojan

Stanojković, Tatjana

Kaluđerović, Goran N.

Article (Published version)
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A novel triphenyltin(IV) compound with 1-(4-carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione was synthesized and characterized by IR, NMR spectroscopy, mass spectrometry, and elemental analysis. In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. The results indicate that complex exhibited very high antiproliferative activity against all tested cell lines with IC 50 values in the range of 0.22 to 0.53 µ M. The highest activity organotin(IV) compound expressed against the HeLa cells (IC 50 = 0.22 ± 0.04 µ M). The ligand precursor did not show anticancer activity (IC 50 > 200 µ M). Furthermore, fluorescence microscopy analysis of HeLa cells reveal that organotin(IV) complex induced apoptosis as a mode of cell death, which is consistent with the increase of cel...ls in the sub-G1 phase.
Source:
Journal of Chemistry, 2019, 2905840-Publisher:
- Hindawi
Funding / projects:
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-172035)
- Biological response modifiers in physiological and pathological conditions (RS-175011)
- National Scholarship for Postdoctoral Studies of the Republic of Serbia (N. Đ. Pantelić)
DOI: 10.1155/2019/2905840
ISSN: 2090-9063
WoS: 000457022700001
Scopus: 2-s2.0-85060787696
URI
https://www.hindawi.com/journals/jchem/2019/2905840/https://cer.ihtm.bg.ac.rs/handle/123456789/2639
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IHTMTY - JOUR AU - Pantelić, Nebojša Đ. AU - Zmejkovski, Bojana AU - Žižak, Željko AU - Banjac, Nebojša R. AU - Božić, Bojan AU - Stanojković, Tatjana AU - Kaluđerović, Goran N. PY - 2019 UR - https://www.hindawi.com/journals/jchem/2019/2905840/ UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2639 AB - A novel triphenyltin(IV) compound with 1-(4-carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione was synthesized and characterized by IR, NMR spectroscopy, mass spectrometry, and elemental analysis. In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. The results indicate that complex exhibited very high antiproliferative activity against all tested cell lines with IC 50 values in the range of 0.22 to 0.53 µ M. The highest activity organotin(IV) compound expressed against the HeLa cells (IC 50 = 0.22 ± 0.04 µ M). The ligand precursor did not show anticancer activity (IC 50 > 200 µ M). Furthermore, fluorescence microscopy analysis of HeLa cells reveal that organotin(IV) complex induced apoptosis as a mode of cell death, which is consistent with the increase of cells in the sub-G1 phase. PB - Hindawi T2 - Journal of Chemistry T2 - Journal of Chemistry T1 - Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione SP - 2905840 DO - 10.1155/2019/2905840 ER -
@article{ author = "Pantelić, Nebojša Đ. and Zmejkovski, Bojana and Žižak, Željko and Banjac, Nebojša R. and Božić, Bojan and Stanojković, Tatjana and Kaluđerović, Goran N.", year = "2019", abstract = "A novel triphenyltin(IV) compound with 1-(4-carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione was synthesized and characterized by IR, NMR spectroscopy, mass spectrometry, and elemental analysis. In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. The results indicate that complex exhibited very high antiproliferative activity against all tested cell lines with IC 50 values in the range of 0.22 to 0.53 µ M. The highest activity organotin(IV) compound expressed against the HeLa cells (IC 50 = 0.22 ± 0.04 µ M). The ligand precursor did not show anticancer activity (IC 50 > 200 µ M). Furthermore, fluorescence microscopy analysis of HeLa cells reveal that organotin(IV) complex induced apoptosis as a mode of cell death, which is consistent with the increase of cells in the sub-G1 phase.", publisher = "Hindawi", journal = "Journal of Chemistry, Journal of Chemistry", title = "Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione", pages = "2905840", doi = "10.1155/2019/2905840" }
Pantelić, N. Đ., Zmejkovski, B., Žižak, Ž., Banjac, N. R., Božić, B., Stanojković, T.,& Kaluđerović, G. N.. (2019). Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione. in Journal of Chemistry Hindawi., 2905840. https://doi.org/10.1155/2019/2905840
Pantelić NĐ, Zmejkovski B, Žižak Ž, Banjac NR, Božić B, Stanojković T, Kaluđerović GN. Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione. in Journal of Chemistry. 2019;:2905840. doi:10.1155/2019/2905840 .
Pantelić, Nebojša Đ., Zmejkovski, Bojana, Žižak, Željko, Banjac, Nebojša R., Božić, Bojan, Stanojković, Tatjana, Kaluđerović, Goran N., "Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione" in Journal of Chemistry (2019):2905840, https://doi.org/10.1155/2019/2905840 . .