The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 _mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 _mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 _mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application.
Amfotericin B, nigericin i polimiksin B pokazuju pozitivni inotropni efekat na izolovanu desnu komoru srca pacova. Imajući u vidu nižu toksičnost jonofornih antibiotika u poređenju sa glikozidnim supstancama koje se u farmakoterapiji koriste kao kardiotonici i visoku selektivnost jonofora prema nekim katjonima, dobijeni rezultati ukazuju na moguću upotrebu ovih supstanci u poboljšanju funkcije insuficijentnog miokarda.
TY - JOUR
AU - Gopčević, Kristina
AU - Gojgić-Cvijović, Gordana
AU - Pavlović, Mirjana
AU - Milićević, Živana
AU - Stevanović, D.
PY - 2006
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/249
AB - The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 _mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 _mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 _mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application.
AB - Amfotericin B, nigericin i polimiksin B pokazuju pozitivni inotropni efekat na izolovanu desnu komoru srca pacova. Imajući u vidu nižu toksičnost jonofornih antibiotika u poređenju sa glikozidnim supstancama koje se u farmakoterapiji koriste kao kardiotonici i visoku selektivnost jonofora prema nekim katjonima, dobijeni rezultati ukazuju na moguću upotrebu ovih supstanci u poboljšanju funkcije insuficijentnog miokarda.
T2 - Acta veterinaria
T1 - The membrane active antibiotics effects on rat heart myocardium
T1 - Efekti antibiotika koji deluju na ćelijske membrane na srce pacova
VL - 56
IS - 2-3
SP - 149
EP - 156
DO - 10.2298/AVB0603149G
ER -
@article{
author = "Gopčević, Kristina and Gojgić-Cvijović, Gordana and Pavlović, Mirjana and Milićević, Živana and Stevanović, D.",
year = "2006",
abstract = "The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 _mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 _mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 _mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application., Amfotericin B, nigericin i polimiksin B pokazuju pozitivni inotropni efekat na izolovanu desnu komoru srca pacova. Imajući u vidu nižu toksičnost jonofornih antibiotika u poređenju sa glikozidnim supstancama koje se u farmakoterapiji koriste kao kardiotonici i visoku selektivnost jonofora prema nekim katjonima, dobijeni rezultati ukazuju na moguću upotrebu ovih supstanci u poboljšanju funkcije insuficijentnog miokarda.",
journal = "Acta veterinaria",
title = "The membrane active antibiotics effects on rat heart myocardium, Efekti antibiotika koji deluju na ćelijske membrane na srce pacova",
volume = "56",
number = "2-3",
pages = "149-156",
doi = "10.2298/AVB0603149G"
}
Gopčević, K., Gojgić-Cvijović, G., Pavlović, M., Milićević, Ž.,& Stevanović, D.. (2006). The membrane active antibiotics effects on rat heart myocardium. in Acta veterinaria, 56(2-3), 149-156.
https://doi.org/10.2298/AVB0603149G
Gopčević K, Gojgić-Cvijović G, Pavlović M, Milićević Ž, Stevanović D. The membrane active antibiotics effects on rat heart myocardium. in Acta veterinaria. 2006;56(2-3):149-156.
doi:10.2298/AVB0603149G .
Gopčević, Kristina, Gojgić-Cvijović, Gordana, Pavlović, Mirjana, Milićević, Živana, Stevanović, D., "The membrane active antibiotics effects on rat heart myocardium" in Acta veterinaria, 56, no. 2-3 (2006):149-156,
https://doi.org/10.2298/AVB0603149G . .
