The membrane active antibiotics effects on rat heart myocardium
Efekti antibiotika koji deluju na ćelijske membrane na srce pacova

2006
Authors
Gopčević, KristinaGojgić-Cvijović, Gordana

Pavlović, Mirjana
Milićević, Živana
Stevanović, D.
Article (Published version)

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The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 _mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 _mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 _mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application.
Amfotericin B, nigericin i polimiksin B pokazuju pozitivni inotropni efekat na izolovanu desnu komoru srca pacova. Imajući u vidu nižu toksičnost jonofornih antibiotika u poređenju sa glikozidnim supstancama koje se u farmakoterapiji koriste kao kardiotonici i visoku selektivnost jonofora prema nekim katjonima, dobijeni rezultati ukazuju na moguću upotrebu ovih supstanci u poboljšanju funkcije insuficijentnog miokarda.
Keywords:
ionophores / myocardium / inotropicSource:
Acta veterinaria, 2006, 56, 2-3, 149-156
DOI: 10.2298/AVB0603149G
ISSN: 0567-8315
WoS: 000238491800005
Scopus: 2-s2.0-33745865513
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IHTMTY - JOUR AU - Gopčević, Kristina AU - Gojgić-Cvijović, Gordana AU - Pavlović, Mirjana AU - Milićević, Živana AU - Stevanović, D. PY - 2006 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/249 AB - The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 _mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 _mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 _mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application. AB - Amfotericin B, nigericin i polimiksin B pokazuju pozitivni inotropni efekat na izolovanu desnu komoru srca pacova. Imajući u vidu nižu toksičnost jonofornih antibiotika u poređenju sa glikozidnim supstancama koje se u farmakoterapiji koriste kao kardiotonici i visoku selektivnost jonofora prema nekim katjonima, dobijeni rezultati ukazuju na moguću upotrebu ovih supstanci u poboljšanju funkcije insuficijentnog miokarda. T2 - Acta veterinaria T1 - The membrane active antibiotics effects on rat heart myocardium T1 - Efekti antibiotika koji deluju na ćelijske membrane na srce pacova VL - 56 IS - 2-3 SP - 149 EP - 156 DO - 10.2298/AVB0603149G ER -
@article{ author = "Gopčević, Kristina and Gojgić-Cvijović, Gordana and Pavlović, Mirjana and Milićević, Živana and Stevanović, D.", year = "2006", abstract = "The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 _mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 _mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 _mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application., Amfotericin B, nigericin i polimiksin B pokazuju pozitivni inotropni efekat na izolovanu desnu komoru srca pacova. Imajući u vidu nižu toksičnost jonofornih antibiotika u poređenju sa glikozidnim supstancama koje se u farmakoterapiji koriste kao kardiotonici i visoku selektivnost jonofora prema nekim katjonima, dobijeni rezultati ukazuju na moguću upotrebu ovih supstanci u poboljšanju funkcije insuficijentnog miokarda.", journal = "Acta veterinaria", title = "The membrane active antibiotics effects on rat heart myocardium, Efekti antibiotika koji deluju na ćelijske membrane na srce pacova", volume = "56", number = "2-3", pages = "149-156", doi = "10.2298/AVB0603149G" }
Gopčević, K., Gojgić-Cvijović, G., Pavlović, M., Milićević, Ž.,& Stevanović, D.. (2006). The membrane active antibiotics effects on rat heart myocardium. in Acta veterinaria, 56(2-3), 149-156. https://doi.org/10.2298/AVB0603149G
Gopčević K, Gojgić-Cvijović G, Pavlović M, Milićević Ž, Stevanović D. The membrane active antibiotics effects on rat heart myocardium. in Acta veterinaria. 2006;56(2-3):149-156. doi:10.2298/AVB0603149G .
Gopčević, Kristina, Gojgić-Cvijović, Gordana, Pavlović, Mirjana, Milićević, Živana, Stevanović, D., "The membrane active antibiotics effects on rat heart myocardium" in Acta veterinaria, 56, no. 2-3 (2006):149-156, https://doi.org/10.2298/AVB0603149G . .