The membrane active antibiotics effects on rat heart myocardium
Efekti antibiotika koji deluju na ćelijske membrane na srce pacova

2006
Authors
Gopčević, KristinaGojgić-Cvijović, Gordana

Pavlović, Mirjana
Milićević, Živana
Stevanović, D.
Article (Published version)

Metadata
Show full item recordAbstract
The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 _mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 _mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 _mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application.
Amfotericin B, nigericin i polimiksin B pokazuju pozitivni inotropni efekat na izolovanu desnu komoru srca pacova. Imajući u vidu nižu toksičnost jonofornih antibiotika u poređenju sa glikozidnim supstancama koje se u farmakoterapiji koriste kao kardiotonici i visoku selektivnost jonofora prema nekim katjonima, dobijeni rezultati ukazuju na moguću upotrebu ovih supstanci u poboljšanju funkcije insuficijentnog miokarda.
Keywords:
ionophores / myocardium / inotropicSource:
Acta veterinaria, 2006, 56, 2-3, 149-156
DOI: 10.2298/AVB0603149G
ISSN: 0567-8315