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Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine

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2018
2483.pdf (2.382Mb)
Authors
Đorđević, Neda O.
Todorović, Nevena
Novaković, Irena
Pezo, Lato
Pejin, Boris
Maras, Vesna
Tešević, Vele
Pajovic, Snezana B.
Article (Published version)
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Abstract
Screens of antioxidant activity (AA) of various natural products have been a focus of the research community worldwide. This work aimed to differentiate selected samples of Merlot wines originated from Montenegro, with regard to phenolic profile and antioxidant capacity studied by survival rate, total sulfhydryl groups and activities of glutathione peroxidase (GPx), glutathione reductase and catalase in H2O2-stressed Saccharomyces cerevisiae cells. In this study, DPPH assay was also performed. Higher total phenolic content leads to an enhanced AA under both conditions. The same trend was observed for catechin and gallic acid, the most abundant phenolics in the examined wine samples. Finally, the findings of an Artificial Neural Network (ANN) model were in a good agreement (r(2) = 0.978) with the experimental data. All tested samples exhibited a protective effect in H2O2-stressed yeast cells. Pre-treatment with examined wines increased survival in H2O2-stressed cells and shifted antioxi...dative defense towards GPx-mediated defense. Finally, sensitivity analysis of obtained ANN model highlights the complexity of the impact that variations in the concentrations of specific phenolic components have on the antioxidant defense system.

Keywords:
red wine / polyphenolics / antioxidant activity / Saccharomyces cerevisiae / artificial neural network
Source:
Molecules, 2018, 23, 8
Publisher:
  • Mdpi, Basel
Projects:
  • Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications (RS-41027)
  • Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)

DOI: 10.3390/molecules23081971

ISSN: 1420-3049

PubMed: 30087228

WoS: 000445295500136

Scopus: 2-s2.0-85052383450
[ Google Scholar ]
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/2485
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