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dc.creatorGođevac, Dejan
dc.creatorDamjanovic, Ana
dc.creatorStanojković, Tatjana
dc.creatorAnđelković, Boban D.
dc.creatorZdunić, Gordana
dc.date.accessioned2019-01-30T18:01:04Z
dc.date.available2019-01-30T18:01:04Z
dc.date.issued2018
dc.identifier.issn0731-7085
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2464
dc.description.abstractHerein, we propose a H-1 NMR-based metabolomics method to reveal cytotoxic metabolites from Mahonia aquifolium stem-bark. Primary and secondary metabolites in the Mahonia aquifolium extracts were identified by thorough analysis of H-1 and 2D NMR spectra, without prior isolation. An OPLS multivariate analysis method was used to correlate the chemical composition of the plant extracts with the results of cytotoxic activity against Human cervical adenocarcinoma cell line. Protoberberine alkaloids berberine and palmatine, along with bisbenzylisoquinoline alkaloid berbamine were identified as the most influential in the OPLS model, with the highest cytotoxic activity.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical and Biomedical Analysis
dc.subjectCytotoxic activityen
dc.subjectNMRen
dc.subjectMetabolomicsen
dc.subjectMahonia aquifoliumen
dc.titleIdentification of cytotoxic metabolites from Mahonia aquifolium using H-1 NMR-based metabolomics approachen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГођевац, Дејан; Aнђелковић, Бобан Д.; Здуниц, Гордана; Станојковиц, Татјана П.; Дамјановиц, Aна;
dc.citation.volume150
dc.citation.spage9
dc.citation.epage14
dc.citation.other150: 9-14
dc.citation.rankM21
dc.identifier.pmid29202306
dc.identifier.doi10.1016/j.jpba.2017.11.075
dc.identifier.rcubConv_3862
dc.identifier.scopus2-s2.0-85036522547
dc.identifier.wos000423497000002
dc.type.versionpublishedVersion


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