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Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers

Authorized Users Only
2018
Authors
Filipović, Vuk
Nedeljkovic, Biljana D. Bozic
Vukomanović, Marija
Tomić, Simonida Lj.
Article (Published version)
Metadata
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Abstract
Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized reveali...ng that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.

Keywords:
HEMA / PBAE / Biocompatible / Degradable / Porous scaffolds
Source:
Polymer Testing, 2018, 68, 270-278
Publisher:
  • Elsevier Sci Ltd, Oxford
Funding / projects:
  • SCOPES programme of the Swiss National Science Foundation
  • Swiss Agency for Development and Cooperation - IZ73ZO_152327
  • Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-172062)
  • Geologic and ecotoxicologic research in identification of geopathogen zones of toxic elements in drinking water reservoirs- research into methods and procedures for reduction of biochemical anomalies (RS-176018)
Note:
  • The peer-reviewed version: https://cer.ihtm.bg.ac.rs/handle/123456789/4293

DOI: 10.1016/j.polymertesting.2018.04.024

ISSN: 0142-9418

WoS: 000437076000034

Scopus: 2-s2.0-85046032696
[ Google Scholar ]
15
10
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/2440
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Filipović, Vuk
AU  - Nedeljkovic, Biljana D. Bozic
AU  - Vukomanović, Marija
AU  - Tomić, Simonida Lj.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2440
AB  - Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.
PB  - Elsevier Sci Ltd, Oxford
T2  - Polymer Testing
T1  - Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers
VL  - 68
SP  - 270
EP  - 278
DO  - 10.1016/j.polymertesting.2018.04.024
ER  - 
@article{
author = "Filipović, Vuk and Nedeljkovic, Biljana D. Bozic and Vukomanović, Marija and Tomić, Simonida Lj.",
year = "2018",
abstract = "Gelatin hydrogels have great potential in regenerative medicine but their weak mechanical properties are a major drawback for the load-bearing applications, such as scaffolds for tissue engineering. To overcome this deficiency, novel biodegradable hydrogels with improved mechanical properties were prepared by combining gelatine with 2-hydroxyethyl methacrylate (HEMA), using a double network synthetic procedure. The first, superporous and mechanically strong network, was obtained by free radical polymerization of HEMA at cryogenic temperature, in the presence of gelatin. Degradable poly (beta-amino ester) (PBAE) macromers of different chemical composition or molecular weight were used as crosslinkers to introduce hydrolytically labile bonds in PHEMA. The second gelatin network was formed by crosslinking gelatin with glutaraldehyde. For comparison, a set of biodegradable PHEMA networks was obtained by polymerization of HEMA at cryogenic temperature. All samples were characterized revealing that mechanical strength, swelling behavior and degradation rate as well as high biocompatibility of new IPNs are in accordance with values required for scaffolds in tissue engineering applications and that tuning of these properties is accomplished by simply using different PBAE macromers.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Polymer Testing",
title = "Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers",
volume = "68",
pages = "270-278",
doi = "10.1016/j.polymertesting.2018.04.024"
}
Filipović, V., Nedeljkovic, B. D. B., Vukomanović, M.,& Tomić, S. Lj.. (2018). Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. in Polymer Testing
Elsevier Sci Ltd, Oxford., 68, 270-278.
https://doi.org/10.1016/j.polymertesting.2018.04.024
Filipović V, Nedeljkovic BDB, Vukomanović M, Tomić SL. Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers. in Polymer Testing. 2018;68:270-278.
doi:10.1016/j.polymertesting.2018.04.024 .
Filipović, Vuk, Nedeljkovic, Biljana D. Bozic, Vukomanović, Marija, Tomić, Simonida Lj., "Biocompatible and degradable scaffolds based on 2-hydroxyethyl methacrylate, gelatin and poly(beta amino ester) crosslinkers" in Polymer Testing, 68 (2018):270-278,
https://doi.org/10.1016/j.polymertesting.2018.04.024 . .

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