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dc.creatorZukic, Selma
dc.creatorVeljović, Elma
dc.creatorSpirtovic-Halilovic, Selma
dc.creatorMuratovic, Samija
dc.creatorOsmanovic, Amar
dc.creatorTrifunović, Snežana
dc.creatorNovaković, Irena
dc.creatorZavrsnik, Davorka
dc.date.accessioned2019-01-30T18:00:19Z
dc.date.available2019-01-30T18:00:19Z
dc.date.issued2018
dc.identifier.issn0011-1643
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2430
dc.description.abstractTen biologically active 2,2,5,5-tetramethy1-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Synthesized compounds were scanned for their antioxidant, antimicrobial and antiproliferative activity. Antibacterial activity was tested by the diffusion and dilution method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, while a ntifunga I activity was tested against Candida albicans and Saccharomyces cerevisiae. Antiproliferative activity was tested against HeLa (cervical carcinoma), SW620 (colorectal adenocarcinoma, metastatic), hepatocellular carcinoma (HEpG2), lung carcinoma cells (A549) and mouse embryo fibroblast cell line (3T3). The best antioxidant activity showed compound 2 with two hydroxy groups substituted on phenyl ring in positions 2' and 3'. The best antimicrobial activity of all synthesized compounds showed compound 8, while the best antiproliferative activity showed compound 6. Results signify the importance of xanthene-1,8-dione derivatives as potential antioxidant and antiproliferative agents.en
dc.publisherCroatian Chemical Soc, Zagreb
dc.rightsopenAccess
dc.sourceCroatica Chemica Acta
dc.subjectxanthene-1,8-dionesen
dc.subjectantimicrobial activityen
dc.subjectantiproliferative activityen
dc.subjectantioxidant potencyen
dc.titleAntioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivativesen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractВељовиц, Елма; Трифуновиц, Снезана; Муратовиц, Самија; Спиртовиц-Халиловиц, Селма; Османовиц, Aмар; Заврсник, Даворка; Зукиц, Селма; Новаковић, Ирена;
dc.citation.volume91
dc.citation.issue1
dc.citation.spage1
dc.citation.epage9
dc.citation.other91(1): 1-9
dc.citation.rankM23
dc.identifier.doi10.5562/cca3225
dc.identifier.rcubConv_4007
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8792/2428.pdf
dc.identifier.scopus2-s2.0-85047193004
dc.identifier.wos000447334900001
dc.type.versionpublishedVersion


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