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dc.creatorSavic, Nada D.
dc.creatorVojnovic, Sandra
dc.creatorGlisic, Biljana D.
dc.creatorCrochet, Aurelien
dc.creatorPavić, Aleksandar
dc.creatorJanjić, Goran
dc.creatorPekmezovic, Marina
dc.creatorOpsenica, Igor
dc.creatorFromm, Katharina M.
dc.creatorNikodinović-Runić, Jasmina
dc.creatorĐuran, Miloš
dc.date.accessioned2019-01-30T18:00:19Z
dc.date.available2019-01-30T18:00:19Z
dc.date.issued2018
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2429
dc.description.abstractMononuclear silver(I) complexes with 1,7-phenanthroline (1,7-phen), [Ag(NO3-O,O') (1,7-phen-N7)(2)] (1) and [Ag(1,7-phen-N7)(2)]X, X = ClO4- (2), CF3SO3- (3), BF4- (4) and SbF6- (5) were synthesized and structurally characterized by NMR (H-1 and C-13), IR and UV-Vis spectroscopy and ESI mass spectrometry. The crystal structures of 1, 3 and 4 were determined by single-crystal X-ray diffraction analysis. In all these complexes, 1,7-phen coordinates to the Ag(I) ion in a monodentate fashion via the less sterically hindered N7 nitrogen atom. The investigation of the solution stability of 1-5 in DMSO revealed that they are sufficiently stable in this solvent at room temperature. Complexes 1-5 showed selectivity towards Candida spp. in comparison to bacteria, effectively inhibiting the growth of four different Candida species with minimal inhibitory concentrations (MIC) between 1.2 and 11.3 mu M. Based on the lowest MIC values and the lowest cytotoxicity against healthy human fibroblasts with selectivity index of more than 30, the antifungal potential was examined in detail for the complex 1. It had the ability to attenuate C. albicans virulence and to reduce epithelial cell damage in the cell infection model. Induction of reactive oxygen species (ROS) response has been detected in C. albicans, with fungal DNA being one of the possible target biomolecules. The toxicity profile of 1 in the zebrafish model (Danio rerio) revealed improved safety and activity in comparison to that of clinically utilized silver(I) sulfadiazine.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172036/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173048/RS//
dc.relationEuropean Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie
dc.relationSupra-MedChem"Balkans.Net SCOPES Institutional Partnership [IZ74Z0_160515]
dc.relationEuropean Unions Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie [642095]
dc.relationSerbian Academy of Sciences and Arts [F128]
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectSilver(I) complexesen
dc.subjectAntimicrobial activityen
dc.subjectCytotoxicityen
dc.subjectCandidaen
dc.subjectDanio rerioen
dc.titleMononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growthen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГлисиц, Биљана Д.; Никодиновиц-Руниц, Јасмина; Опсеница, Игор М.; Јањић, Горан; Фромм, Катхарина М.; Пекмезовиц, Марина; Цроцхет, Aурелиен; Савиц, Нада Д.; Војновиц, Сандра; Павиц, Aлександар; Дјуран, Милос И.;
dc.citation.volume156
dc.citation.spage760
dc.citation.epage773
dc.citation.other156: 760-773
dc.citation.rankaM21
dc.identifier.pmid30053719
dc.identifier.doi10.1016/j.ejmech.2018.07.049
dc.identifier.rcubConv_3985
dc.identifier.scopus2-s2.0-85050292358
dc.identifier.wos000443663200056
dc.type.versionpublishedVersion


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