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dc.creatorKonstantinović, Jelena M.
dc.creatorVidenović, Milica
dc.creatorOrsini, Stefania
dc.creatorBogojević, Katarina
dc.creatorD'Alessandro, Sarah
dc.creatorScaccabarozzi, Diletta
dc.creatorTerzić-Jovanović, Nataša
dc.creatorGradoni, Luigi
dc.creatorBasilico, Nicoletta
dc.creatorŠolaja, Bogdan
dc.date.accessioned2019-01-30T18:00:18Z
dc.date.available2019-01-30T18:00:18Z
dc.date.issued2018
dc.identifier.issn1948-5875
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2428
dc.description.abstractIn this Letter, a detailed analysis of 30 4-aminoquinoline-based compounds with regard to their potential as antileishmanial drugs has been carried out. Ten compounds demonstrated IC50 LT 1 mu M against promastigote stages of L. infantum and L. tropica, and five compounds showed IC50 LT 1 mu M against intramacrophage L. infantum amastigotes. Two compounds showed dose-dependent enhancement of NO and ROS production by bone marrow-derived macrophages and remarkable reduction of parasite load in vivo, with advantage of being short-term and orally active. To the best of our knowledge, this is the first example of 4-amino-7-chloroquinoline derivatives active in Leishmania infantum infected mice.en
dc.publisherAmerican Chemical Society (ACS)
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172008/RS//
dc.relationMinistero dellIstruzione, dellUniversita e della Ricerca (PRIN) Project [20154JRJPP_004]
dc.relationSerbian Academy of Sciences and Arts, Executive Programme of Scientific and Technological Cooperation between the Italian Republic and the Republic of Serbia
dc.rightsrestrictedAccess
dc.sourceAcs Medicinal Chemistry Letters
dc.subjectLeishmania infantumen
dc.subjectpromastigoteen
dc.subjectamastigoteen
dc.subjectmice modelen
dc.subjectaminoquinolineen
dc.titleNovel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania infantum Infected Miceen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБогојевиц, Катарина; Орсини, Стефаниа; Д'Aлессандро, Сарах; Басилицо, Ницолетта; Солаја, Богдан A.; Терзић Јовановић, Наташа; Виденовиц, Милица; Сцаццабароззи, Дилетта; Градони, Луиги; Константиновиц, Јелена;
dc.citation.volume9
dc.citation.issue7
dc.citation.spage629
dc.citation.epage634
dc.citation.other9(7): 629-634
dc.citation.rankM21
dc.description.otherPeer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/3626]
dc.identifier.pmid30034591
dc.identifier.doi10.1021/acsmedchemlett.8b00053
dc.identifier.rcubConv_3984
dc.identifier.scopus2-s2.0-85046787760
dc.identifier.wos000442964000011
dc.type.versionpublishedVersion


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