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dc.creatorNikolić, Ines
dc.creatorLunter, Dominique Jasmin
dc.creatorRanđelović, Danijela
dc.creatorZugic, Ana
dc.creatorTadić, Vanja
dc.creatorMarković, Bojan D.
dc.creatorCekic, Nebojsa
dc.creatorŽivković, Lada
dc.creatorTopalovic, Dijana
dc.creatorSpremo-Potparević, Biljana
dc.creatorDaniels, Rolf
dc.creatorSavić, Snežana D.
dc.date.accessioned2019-01-30T18:00:14Z
dc.date.available2019-01-30T18:00:14Z
dc.date.issued2018
dc.identifier.issn0378-5173
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2425
dc.description.abstractThe objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for deepening the knowledge on their formation via spontaneous emulsification. Curcumin, a compound of natural origin, potentially powerful therapeutic, was chosen as a model API. Due to curcumin's demanding properties (instability, poor solubility, low permeability), its potentials remain unreached. Low-energy nanoemulsions were considered carriers capable of overcoming imposed obstacles. Formulation consisting of Polysorbate 80 and soybean lecithin as stabilizers (9:1, 10%), medium-chain triglycerides as the oil phase (10%) and ultrapure water was selected for curcumin incorporation in 3 different concentrations (1, 2 and 3 mg/mL). Physicochemical stability was demonstrated during 3 months of monitoring (mean droplet size: 111.3-146.8 nm; PDI LT 0.2; pH: 4.73-5.73). Curcumin's release from developed vehicles followed Higuchi's kinetics. DPPH (IC50 = 0.1187 mg/ mL) and FRAP (1.19 +/- 0.02 mmol/g) assays confirmed that curcumin acts as a potent antioxidant through different mechanisms, with no alterations after incorporation in the formulation. High biocompatibility in line with antigenotoxic activity of curcumin-loaded formulations (protective and reparative) was estimated through Comet assay. A multidisciplinary approach is needed to fully characterize developed systems, directing them to more concrete application possibilities.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.relationRepublic of Serbia
dc.relationFederal Republic of Germany
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.subjectLow-energy nanoemulsionsen
dc.subjectSpontaneous emulsificationen
dc.subjectCurcuminen
dc.subjectAtomic force microscopyen
dc.subjectAntioxidant activityen
dc.subject(Anti)genotoxicityen
dc.titleCurcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal applicationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦекиц, Небојса; Марковиц, Бојан; Тадиц, Вања; Николиц, Инес; Зивковиц, Лада; Спремо-Потпаревиц, Биљана; Даниелс, Ролф; Савиц, Снезана; Лунтер, Доминиqуе Јасмин; Зугиц, Aна; Топаловиц, Дијана; Ранђеловић, Данијела;
dc.citation.volume550
dc.citation.issue1-2
dc.citation.spage333
dc.citation.epage346
dc.citation.other550(1-2): 333-346
dc.citation.rankM21
dc.description.otherThe peer-reviewed version: [https://cer.ihtm.bg.ac.rs/handle/123456789/3719]
dc.identifier.pmid30179702
dc.identifier.doi10.1016/j.ijpharm.2018.08.060
dc.identifier.rcubConv_3992
dc.identifier.scopus2-s2.0-85052734341
dc.identifier.wos000445147000033
dc.type.versionpublishedVersion


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