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Evaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test models

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2018
Authors
Đorđević, J.
Kolarević, S.
Jovanović, J.
Kostić-Vuković, J.
Novaković, Irena
Jeremić, M.
Sladić, Dušan
Vuković-Gačić, Branka
Article (Published version)
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Abstract
Tert-butylquinone (TBQ) and its alkylamino and aralkylamino derivatives are of high interest as a potential antitumor agent. Therefore, it was necessary to investigate if the compounds exert undesirable activities such as interaction with DNA molecule which could result in negative side effects in the case of their use in the diseases treatment. The major aim of this study was to investigate genotoxic potential of TBQ and selected derivatives in an acellular model by using plasmid DNA, in the prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002 and in eukaryotic models by using comet assay in human fetal lung cell line (MRC-5) and human liver cancer cell line (HepG2). Results indicated that in the acellular model TBQ and its derivatives do not interact with plasmid pUC19. In the prokaryotic model, only TBQ exerted weak genotoxic potential and only at highly cytotoxic concentrations. In eukaryotic models, genotoxic potential was detected mainly at the highest... concentrations of the tested substances but the effect was lower in both cell lines in comparison with benzo[a]pyrene and etoposide which were used as positive controls. Weak genotoxic potential of tested compounds recommends them as good candidates for further testing in development of new antitumor agents.

Keywords:
alkylamino and aralkylamino derivatives / comet assay / genotoxicity / plasmid relaxation / SOS/umuC / Tert-butylquinone
Source:
Drug and Chemical Toxicology, 2018
Publisher:
  • Taylor and Francis Ltd
Projects:
  • Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
  • Bioactive natural products as potential sources of new pharmaceuticals and food supplements (RS-172058)

DOI: 10.1080/01480545.2018.1514043

ISSN: 0148-0545

WoS: 000551592600008

Scopus: 2-s2.0-85053908360
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/2415
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IHTM

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