This study evaluates the genotoxic potential of two Ru(III) complexes with thiosemicarbazone based ligands. The complexes were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using the cytokinesis block micronucleus (CBMN) assay at concentrations 1.5; 3.7 and 7.4 μg/mL. The cell culture treated with the tested complexes, at 3.7 μg/mL concentration, decreased a frequency of micronucleus for 37% and 32%, when compared with the control cell cultures. At concentration of 7.4 (1.5) μg/mL of this complexes exhibited slightly lower effect of micronucleus for 30% (35%) and 27% (29%), when compared with the control cell cultures.
TY - JOUR
AU - Ljubijankić, N.
AU - Stanković, M.
AU - Tešević, Vele
AU - Grgurić-Šipka, Sanja
AU - Jadranin, Milka
AU - Begić, Sabina
AU - Šabanović, E.
PY - 2018
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2407
AB - This study evaluates the genotoxic potential of two Ru(III) complexes with thiosemicarbazone based ligands. The complexes were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using the cytokinesis block micronucleus (CBMN) assay at concentrations 1.5; 3.7 and 7.4 μg/mL. The cell culture treated with the tested complexes, at 3.7 μg/mL concentration, decreased a frequency of micronucleus for 37% and 32%, when compared with the control cell cultures. At concentration of 7.4 (1.5) μg/mL of this complexes exhibited slightly lower effect of micronucleus for 30% (35%) and 27% (29%), when compared with the control cell cultures.
PB - Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma
T2 - Rasayan Journal of Chemistry
T1 - Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro
VL - 11
IS - 2
SP - 647
EP - 652
DO - 10.31788/RJC.2018.1123004
ER -
@article{
author = "Ljubijankić, N. and Stanković, M. and Tešević, Vele and Grgurić-Šipka, Sanja and Jadranin, Milka and Begić, Sabina and Šabanović, E.",
year = "2018",
abstract = "This study evaluates the genotoxic potential of two Ru(III) complexes with thiosemicarbazone based ligands. The complexes were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using the cytokinesis block micronucleus (CBMN) assay at concentrations 1.5; 3.7 and 7.4 μg/mL. The cell culture treated with the tested complexes, at 3.7 μg/mL concentration, decreased a frequency of micronucleus for 37% and 32%, when compared with the control cell cultures. At concentration of 7.4 (1.5) μg/mL of this complexes exhibited slightly lower effect of micronucleus for 30% (35%) and 27% (29%), when compared with the control cell cultures.",
publisher = "Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma",
journal = "Rasayan Journal of Chemistry",
title = "Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro",
volume = "11",
number = "2",
pages = "647-652",
doi = "10.31788/RJC.2018.1123004"
}
Ljubijankić, N., Stanković, M., Tešević, V., Grgurić-Šipka, S., Jadranin, M., Begić, S.,& Šabanović, E.. (2018). Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro. in Rasayan Journal of Chemistry
Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma., 11(2), 647-652.
https://doi.org/10.31788/RJC.2018.1123004
Ljubijankić N, Stanković M, Tešević V, Grgurić-Šipka S, Jadranin M, Begić S, Šabanović E. Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro. in Rasayan Journal of Chemistry. 2018;11(2):647-652.
doi:10.31788/RJC.2018.1123004 .
Ljubijankić, N., Stanković, M., Tešević, Vele, Grgurić-Šipka, Sanja, Jadranin, Milka, Begić, Sabina, Šabanović, E., "Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro" in Rasayan Journal of Chemistry, 11, no. 2 (2018):647-652,
https://doi.org/10.31788/RJC.2018.1123004 . .
