New aurone epoxide, 2,10-oxy-10-methoxysulfuretin (14), and new auronolignan (15), named cotinignan A, were isolated by silica gel column and semipreparative HPLC chromatography from the methylene chloride/methanol extract of Cotinus coggygria Scop. heartwood. In addition, thirteen known secondary metabolites namely sulfuretin, 2,3-trans-fustin, fisetin, butin, butein, taxifolin, eriodictyol, 3',5,5',7–tetrahydroxyflavanone, 3',4',7-trihydroxyflavone, 3-O-methyl-2,3-trans-fustin, 3-O-galloyl-2,3-trans-fustin, β-resorcylic acid and 3-O-β-sitosterol glucoside were isolated as well. Their structures were elucidated by 1D and 2D NMR, HR-ESI-MS, IR and UV. Ten out of eleven isolated flavonoids possess 7, 3' and 4' hydroxy groups. These structural features could be considered as chemotaxonomic characteristic of flavonoids from C. coggygria. Cotinignan A (15) represents new subclass of secondary metabolites - auronolignans. (Figure presented.).
TY - JOUR
AU - Novaković, Miroslav
AU - Đorđević, Iris
AU - Todorović, Nina
AU - Trifunovic, S.
AU - Anđelković, Boban D.
AU - Mandić, Boris
AU - Jadranin, Milka
AU - Vučković, Ivan
AU - Vajs, Vlatka
AU - Milosavljević, Slobodan
AU - Tešević, Vele
PY - 2018
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/2389
AB - New aurone epoxide, 2,10-oxy-10-methoxysulfuretin (14), and new auronolignan (15), named cotinignan A, were isolated by silica gel column and semipreparative HPLC chromatography from the methylene chloride/methanol extract of Cotinus coggygria Scop. heartwood. In addition, thirteen known secondary metabolites namely sulfuretin, 2,3-trans-fustin, fisetin, butin, butein, taxifolin, eriodictyol, 3',5,5',7–tetrahydroxyflavanone, 3',4',7-trihydroxyflavone, 3-O-methyl-2,3-trans-fustin, 3-O-galloyl-2,3-trans-fustin, β-resorcylic acid and 3-O-β-sitosterol glucoside were isolated as well. Their structures were elucidated by 1D and 2D NMR, HR-ESI-MS, IR and UV. Ten out of eleven isolated flavonoids possess 7, 3' and 4' hydroxy groups. These structural features could be considered as chemotaxonomic characteristic of flavonoids from C. coggygria. Cotinignan A (15) represents new subclass of secondary metabolites - auronolignans. (Figure presented.).
PB - Taylor and Francis Ltd.
T2 - Natural Product Research
T1 - New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop
VL - 33
IS - 19
SP - 2837
EP - 2844
DO - 10.1080/14786419.2018.1508141
ER -
@article{
author = "Novaković, Miroslav and Đorđević, Iris and Todorović, Nina and Trifunovic, S. and Anđelković, Boban D. and Mandić, Boris and Jadranin, Milka and Vučković, Ivan and Vajs, Vlatka and Milosavljević, Slobodan and Tešević, Vele",
year = "2018",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/2389",
abstract = "New aurone epoxide, 2,10-oxy-10-methoxysulfuretin (14), and new auronolignan (15), named cotinignan A, were isolated by silica gel column and semipreparative HPLC chromatography from the methylene chloride/methanol extract of Cotinus coggygria Scop. heartwood. In addition, thirteen known secondary metabolites namely sulfuretin, 2,3-trans-fustin, fisetin, butin, butein, taxifolin, eriodictyol, 3',5,5',7–tetrahydroxyflavanone, 3',4',7-trihydroxyflavone, 3-O-methyl-2,3-trans-fustin, 3-O-galloyl-2,3-trans-fustin, β-resorcylic acid and 3-O-β-sitosterol glucoside were isolated as well. Their structures were elucidated by 1D and 2D NMR, HR-ESI-MS, IR and UV. Ten out of eleven isolated flavonoids possess 7, 3' and 4' hydroxy groups. These structural features could be considered as chemotaxonomic characteristic of flavonoids from C. coggygria. Cotinignan A (15) represents new subclass of secondary metabolites - auronolignans. (Figure presented.).",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop",
volume = "33",
number = "19",
pages = "2837-2844",
doi = "10.1080/14786419.2018.1508141"
}
Novaković M, Đorđević I, Todorović N, Trifunovic S, Anđelković BD, Mandić B, Jadranin M, Vučković I, Vajs V, Milosavljević S, Tešević V. New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop. Natural Product Research. 2018;33(19):2837-2844
Novaković, M., Đorđević, I., Todorović, N., Trifunovic, S., Anđelković, B. D., Mandić, B., Jadranin, M., Vučković, I., Vajs, V., Milosavljević, S.,& Tešević, V. (2018). New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop.
Natural Product ResearchTaylor and Francis Ltd.., 33(19), 2837-2844.
https://doi.org/10.1080/14786419.2018.1508141
Novaković Miroslav, Đorđević Iris, Todorović Nina, Trifunovic S., Anđelković Boban D., Mandić Boris, Jadranin Milka, Vučković Ivan, Vajs Vlatka, Milosavljević Slobodan, Tešević Vele, "New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop" 33, no. 19 (2018):2837-2844,
https://doi.org/10.1080/14786419.2018.1508141 .
