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dc.creatorKaraman, M.
dc.creatorTesanovic, K.
dc.creatorNovakovic, A.
dc.creatorJakovljević, Dragica
dc.creatorJanjusevic, L.
dc.creatorSibul, F.
dc.creatorPejin, Boris
dc.date.accessioned2019-01-30T17:59:27Z
dc.date.available2019-01-30T17:59:27Z
dc.date.issued2018
dc.identifier.issn1478-6419
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2388
dc.description.abstractIn vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.en
dc.publisherTaylor and Francis Ltd.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43002/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173040/RS//
dc.rightsrestrictedAccess
dc.sourceNatural Product Research
dc.subjectAChE inhibitory activityen
dc.subjectCoprinus comatus filtrate extracten
dc.subjectnew AD health promoting producten
dc.subjectpolyphenolic profileen
dc.subjectquercetinen
dc.titleCoprinus comatus filtrate extract, a novel neuroprotective agent of natural originen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈаковљевић, Драгица; Новаковиц, A.; Јањусевиц, Л.; Сибул, Ф.; Тесановиц, К.; Пејин, Б.; Караман, М.;
dc.citation.other
dc.citation.rankM22
dc.identifier.doi10.1080/14786419.2018.1533831
dc.identifier.rcubConv_4485
dc.identifier.scopus2-s2.0-85057546516
dc.identifier.wos000561132800017
dc.type.versionpublishedVersion


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