Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin
Samo za registrovane korisnike
2018
Autori
Karaman, M.Tesanovic, K.
Novakovic, A.
Jakovljević, Dragica
Janjusevic, L.
Sibul, F.
Pejin, Boris
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.
Ključne reči:
AChE inhibitory activity / Coprinus comatus filtrate extract / new AD health promoting product / polyphenolic profile / quercetinIzvor:
Natural Product Research, 2018, 34, 16, 2346-2350Izdavač:
- Taylor and Francis Ltd.
Finansiranje / projekti:
- Biosensing tehnologije i globalni sistem za kontinuirana istraživanja i integrisano upravljanje ekosistemima (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43002)
- Modifikacije antioksidativnog metabolizma biljaka sa ciljem povećanja tolerancije na abiotski stres i identifikacija novih biomarkera sa primenom u remedijaciji i monitoringu degradiranih staništa (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43010)
- Razvoj i primena novih i tradicionalnih tehnologija u proizvodnji konkurentnih prehrambenih proizvoda sa dodatom vrednošću za evropsko i svetsko tržište - Stvorimo bogatstvo iz bogatstva Srbije (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46001)
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-MESTD-Basic Research (BR or ON)-172053)
- Biološki aktivni prirodni proizvodi kao potencijalni izvori novih lekova i dijetetskih suplemenata (RS-MESTD-Basic Research (BR or ON)-172058)
- Interakcije membrana sa unutarćelijskim i apoplastičnim prostorom: izučavanja bioenergetike i singalizacije koristeći biofizičke i biohemijske metode (RS-MESTD-Basic Research (BR or ON)-173040)
DOI: 10.1080/14786419.2018.1533831
ISSN: 1478-6419
WoS: 000561132800017
Scopus: 2-s2.0-85057546516
Institucija/grupa
IHTMTY - JOUR AU - Karaman, M. AU - Tesanovic, K. AU - Novakovic, A. AU - Jakovljević, Dragica AU - Janjusevic, L. AU - Sibul, F. AU - Pejin, Boris PY - 2018 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2388 AB - In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry. PB - Taylor and Francis Ltd. T2 - Natural Product Research T1 - Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin VL - 34 IS - 16 SP - 2346 EP - 2350 DO - 10.1080/14786419.2018.1533831 ER -
@article{ author = "Karaman, M. and Tesanovic, K. and Novakovic, A. and Jakovljević, Dragica and Janjusevic, L. and Sibul, F. and Pejin, Boris", year = "2018", abstract = "In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.", publisher = "Taylor and Francis Ltd.", journal = "Natural Product Research", title = "Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin", volume = "34", number = "16", pages = "2346-2350", doi = "10.1080/14786419.2018.1533831" }
Karaman, M., Tesanovic, K., Novakovic, A., Jakovljević, D., Janjusevic, L., Sibul, F.,& Pejin, B.. (2018). Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin. in Natural Product Research Taylor and Francis Ltd.., 34(16), 2346-2350. https://doi.org/10.1080/14786419.2018.1533831
Karaman M, Tesanovic K, Novakovic A, Jakovljević D, Janjusevic L, Sibul F, Pejin B. Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin. in Natural Product Research. 2018;34(16):2346-2350. doi:10.1080/14786419.2018.1533831 .
Karaman, M., Tesanovic, K., Novakovic, A., Jakovljević, Dragica, Janjusevic, L., Sibul, F., Pejin, Boris, "Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin" in Natural Product Research, 34, no. 16 (2018):2346-2350, https://doi.org/10.1080/14786419.2018.1533831 . .