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Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin

Authorized Users Only
2018
Authors
Karaman, M.
Tesanovic, K.
Novakovic, A.
Jakovljević, Dragica
Janjusevic, L.
Sibul, F.
Pejin, Boris
Article (Published version)
Metadata
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Abstract
In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.
Keywords:
AChE inhibitory activity / Coprinus comatus filtrate extract / new AD health promoting product / polyphenolic profile / quercetin
Source:
Natural Product Research, 2018, 34, 16, 2346-2350
Publisher:
  • Taylor and Francis Ltd.
Funding / projects:
  • Biosensing Technologies and Global System for Long-Term Research and Integrated Management of Ecosystems (RS-43002)
  • Modulation of antioxidative metabolism in plants for improvement of plant abiotic stress tolerance and identification of new biomarkers for application in remediation and monitoring of degraded biotopes (RS-43010)
  • Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA (RS-46001)
  • Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
  • Bioactive natural products as potential sources of new pharmaceuticals and food supplements (RS-172058)
  • The membranes as sites of interaction between the intracellular and apoplastic environments: studies of the bioenergetics and signaling using biophysical and biochemical techniques. (RS-173040)

DOI: 10.1080/14786419.2018.1533831

ISSN: 1478-6419

WoS: 000561132800017

Scopus: 2-s2.0-85057546516
[ Google Scholar ]
4
4
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/2388
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Karaman, M.
AU  - Tesanovic, K.
AU  - Novakovic, A.
AU  - Jakovljević, Dragica
AU  - Janjusevic, L.
AU  - Sibul, F.
AU  - Pejin, Boris
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2388
AB  - In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.
PB  - Taylor and Francis Ltd.
T2  - Natural Product Research
T1  - Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin
VL  - 34
IS  - 16
SP  - 2346
EP  - 2350
DO  - 10.1080/14786419.2018.1533831
UR  - Conv_4485
ER  - 
@article{
author = "Karaman, M. and Tesanovic, K. and Novakovic, A. and Jakovljević, Dragica and Janjusevic, L. and Sibul, F. and Pejin, Boris",
year = "2018",
abstract = "In vitro acetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroom Coprinus comatus (encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study. C. comatus F extract exhibited rather potent anti-AChE activity (73.0 ± 1.5%) at in liquid conditions, comparable to those of the conventional drug donepezil (80.6 ± 1.4%). Also, the same extract exhibited high anti-AChE activity (1 µg) in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 µg g−1 d.w.) was found to affect the observed bioactivity (59.8 ± 0.9%). This is the first report of profound anti-AChE activity of any C. comatus extract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin",
volume = "34",
number = "16",
pages = "2346-2350",
doi = "10.1080/14786419.2018.1533831",
url = "Conv_4485"
}
Karaman, M., Tesanovic, K., Novakovic, A., Jakovljević, D., Janjusevic, L., Sibul, F.,& Pejin, B.. (2018). Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin. in Natural Product Research
Taylor and Francis Ltd.., 34(16), 2346-2350.
https://doi.org/10.1080/14786419.2018.1533831
Conv_4485
Karaman M, Tesanovic K, Novakovic A, Jakovljević D, Janjusevic L, Sibul F, Pejin B. Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin. in Natural Product Research. 2018;34(16):2346-2350.
doi:10.1080/14786419.2018.1533831
Conv_4485 .
Karaman, M., Tesanovic, K., Novakovic, A., Jakovljević, Dragica, Janjusevic, L., Sibul, F., Pejin, Boris, "Coprinus comatus filtrate extract, a novel neuroprotective agent of natural origin" in Natural Product Research, 34, no. 16 (2018):2346-2350,
https://doi.org/10.1080/14786419.2018.1533831 .,
Conv_4485 .

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