Show simple item record

dc.creatorVeljović, Elma
dc.creatorSpirtovic-Halilovic, S.
dc.creatorMuratovic, S.
dc.creatorSalihovic, M.
dc.creatorNovaković, Irena
dc.creatorOsmanovic, A.
dc.creatorZavrsnik, D.
dc.date.accessioned2019-01-30T17:59:23Z
dc.date.available2019-01-30T17:59:23Z
dc.date.issued2018
dc.identifier.issn0975-8585
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2383
dc.description.abstractTwelve previously synthesized biologically active 2,6,7-trihydroxy-9-aryl-3H-xanthen-3-one derivatives (1-12) were evaluated in vitro for their antimicrobial activity against four bacteria, S. aureus, B. subtilis P. aeruginosa and E. coli, and two fungi strains, C. albicans and S. cerevisiae. The most potent compound were derivatives 1 which possess hydroxyl group and bromine as substituent and 11 with bromine as substituent on phenyl ring. The results indicate that bromine increase antimicrobial activity of 2,6,7-trihydroxy-9-aryl-3-Hxanthen-3-one derivatives. Compound 7 with ethoxy substituent on phenyl ring showed the least activity against tested bacteria and fungi strains, which is in line with an earlier observation that ethoxy substitution decreases antimicrobial activity. The most and the least potent compounds were subjected to molecular docking simulations to preliminary find out the potential molecular target and at the same moment further support the experimental antimicrobial test of xanthen derivatives.en
dc.rightsopenAccess
dc.sourceResearch Journal of Pharmaceutical Biological and Chemical Sciences
dc.subjectxantheneen
dc.subjectantimicrobial activityen
dc.subjectdocking studyen
dc.titleAntimicrobial Activity and Docking Study of Synthesized Xanthen-3-on Derivativesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНоваковић, Ирена; Османовиц, A.; Заврсник, Д.; Вељовиц, Е.; Спиртовиц-Халиловиц, С.; Муратовиц, С.; Салиховиц, М.;
dc.citation.volume9
dc.citation.issue5
dc.citation.spage777
dc.citation.epage783
dc.citation.other9(5): 777-783
dc.identifier.rcubConv_4004
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/15230/[96].pdf
dc.identifier.wos000447016800096
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record