Antimicrobial Activity and Docking Study of Synthesized Xanthen-3-on Derivatives

2018
Authors
Veljović, ElmaSpirtovic-Halilovic, S.
Muratovic, S.
Salihovic, M.
Novaković, Irena

Osmanovic, A.
Zavrsnik, D.
Article (Published version)

Metadata
Show full item recordAbstract
Twelve previously synthesized biologically active 2,6,7-trihydroxy-9-aryl-3H-xanthen-3-one derivatives (1-12) were evaluated in vitro for their antimicrobial activity against four bacteria, S. aureus, B. subtilis P. aeruginosa and E. coli, and two fungi strains, C. albicans and S. cerevisiae. The most potent compound were derivatives 1 which possess hydroxyl group and bromine as substituent and 11 with bromine as substituent on phenyl ring. The results indicate that bromine increase antimicrobial activity of 2,6,7-trihydroxy-9-aryl-3-Hxanthen-3-one derivatives. Compound 7 with ethoxy substituent on phenyl ring showed the least activity against tested bacteria and fungi strains, which is in line with an earlier observation that ethoxy substitution decreases antimicrobial activity. The most and the least potent compounds were subjected to molecular docking simulations to preliminary find out the potential molecular target and at the same moment further support the experimental antimicrob...ial test of xanthen derivatives.
Keywords:
xanthene / antimicrobial activity / docking studySource:
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2018, 9, 5, 777-783Collections
Institution/Community
IHTMTY - JOUR AU - Veljović, Elma AU - Spirtovic-Halilovic, S. AU - Muratovic, S. AU - Salihovic, M. AU - Novaković, Irena AU - Osmanovic, A. AU - Zavrsnik, D. PY - 2018 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2383 AB - Twelve previously synthesized biologically active 2,6,7-trihydroxy-9-aryl-3H-xanthen-3-one derivatives (1-12) were evaluated in vitro for their antimicrobial activity against four bacteria, S. aureus, B. subtilis P. aeruginosa and E. coli, and two fungi strains, C. albicans and S. cerevisiae. The most potent compound were derivatives 1 which possess hydroxyl group and bromine as substituent and 11 with bromine as substituent on phenyl ring. The results indicate that bromine increase antimicrobial activity of 2,6,7-trihydroxy-9-aryl-3-Hxanthen-3-one derivatives. Compound 7 with ethoxy substituent on phenyl ring showed the least activity against tested bacteria and fungi strains, which is in line with an earlier observation that ethoxy substitution decreases antimicrobial activity. The most and the least potent compounds were subjected to molecular docking simulations to preliminary find out the potential molecular target and at the same moment further support the experimental antimicrobial test of xanthen derivatives. T2 - Research Journal of Pharmaceutical Biological and Chemical Sciences T1 - Antimicrobial Activity and Docking Study of Synthesized Xanthen-3-on Derivatives VL - 9 IS - 5 SP - 777 EP - 783 UR - https://hdl.handle.net/21.15107/rcub_cer_2383 ER -
@article{ author = "Veljović, Elma and Spirtovic-Halilovic, S. and Muratovic, S. and Salihovic, M. and Novaković, Irena and Osmanovic, A. and Zavrsnik, D.", year = "2018", abstract = "Twelve previously synthesized biologically active 2,6,7-trihydroxy-9-aryl-3H-xanthen-3-one derivatives (1-12) were evaluated in vitro for their antimicrobial activity against four bacteria, S. aureus, B. subtilis P. aeruginosa and E. coli, and two fungi strains, C. albicans and S. cerevisiae. The most potent compound were derivatives 1 which possess hydroxyl group and bromine as substituent and 11 with bromine as substituent on phenyl ring. The results indicate that bromine increase antimicrobial activity of 2,6,7-trihydroxy-9-aryl-3-Hxanthen-3-one derivatives. Compound 7 with ethoxy substituent on phenyl ring showed the least activity against tested bacteria and fungi strains, which is in line with an earlier observation that ethoxy substitution decreases antimicrobial activity. The most and the least potent compounds were subjected to molecular docking simulations to preliminary find out the potential molecular target and at the same moment further support the experimental antimicrobial test of xanthen derivatives.", journal = "Research Journal of Pharmaceutical Biological and Chemical Sciences", title = "Antimicrobial Activity and Docking Study of Synthesized Xanthen-3-on Derivatives", volume = "9", number = "5", pages = "777-783", url = "https://hdl.handle.net/21.15107/rcub_cer_2383" }
Veljović, E., Spirtovic-Halilovic, S., Muratovic, S., Salihovic, M., Novaković, I., Osmanovic, A.,& Zavrsnik, D.. (2018). Antimicrobial Activity and Docking Study of Synthesized Xanthen-3-on Derivatives. in Research Journal of Pharmaceutical Biological and Chemical Sciences, 9(5), 777-783. https://hdl.handle.net/21.15107/rcub_cer_2383
Veljović E, Spirtovic-Halilovic S, Muratovic S, Salihovic M, Novaković I, Osmanovic A, Zavrsnik D. Antimicrobial Activity and Docking Study of Synthesized Xanthen-3-on Derivatives. in Research Journal of Pharmaceutical Biological and Chemical Sciences. 2018;9(5):777-783. https://hdl.handle.net/21.15107/rcub_cer_2383 .
Veljović, Elma, Spirtovic-Halilovic, S., Muratovic, S., Salihovic, M., Novaković, Irena, Osmanovic, A., Zavrsnik, D., "Antimicrobial Activity and Docking Study of Synthesized Xanthen-3-on Derivatives" in Research Journal of Pharmaceutical Biological and Chemical Sciences, 9, no. 5 (2018):777-783, https://hdl.handle.net/21.15107/rcub_cer_2383 .