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dc.creatorKostić Rajačić, Slađana
dc.creatorSchwall, Gerhard
dc.creatorPenjišević, Jelena
dc.creatorAndrić, Deana
dc.creatorŠukalović, Vladimir
dc.creatorŠoškić, Vukić
dc.date.accessioned2019-01-30T17:59:13Z
dc.date.available2019-01-30T17:59:13Z
dc.date.issued2018
dc.identifier.issn1747-0277
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2375
dc.description.abstractAffinity chromatography was used to identify potential cellular targets that are responsible for neuroprotective activity of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides. Active and inactive representatives of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides bearing an extended linker were synthesized and immobilized on an agarose-based matrix. This was followed by the identification of specifically bound proteins isolated out of the whole rat brain extract. Inducible flavoprotein NAD(P)H:quinone oxidoreductase (NQO1) was identified as candidates for cellular targets.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172032/RS//
dc.rightsrestrictedAccess
dc.sourceChemical Biology & Drug Design
dc.subjectarylpiperazinesen
dc.subjectferrochelataseen
dc.subjectneuroprotectionen
dc.subjectNQO1en
dc.titleIdentification of NQO1 and ferrochelatase as interaction partners for neuroprotective N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamidesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПењишевић, Јелена; Костић Рајачић, Слађана; Aндриц, Деана; Шукаловић, Владимир; Соскиц, Вукиц; Сцхwалл, Герхард;
dc.citation.volume92
dc.citation.issue1
dc.citation.spage1393
dc.citation.epage1397
dc.citation.other92(1): 1393-1397
dc.citation.rankM22
dc.identifier.pmid29543381
dc.identifier.doi10.1111/cbdd.13193
dc.identifier.rcubConv_3955
dc.identifier.scopus2-s2.0-85045070724
dc.identifier.wos000436403500023
dc.type.versionpublishedVersion


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