The aim of the present study was to examine the oxidative properties and an assay of azithromycin and Hemomycin (R) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry. The maximum value of the current of the oxidation peak of pure azithromycin and azithromycin from Hemomycin (R) at 0.6 V versus SCE in 0.05 M NaHCO3 and in a mixture methanol -0.05 M NaHCO3 (1:1) at a scan rate of 50 mV s(-1) is a linear function of the concentration in the range of 0.235-0.588 mg/cm(3). HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the values of the current peak concerning the concentration of antibiotic in the investigated concentration range. The role of methanol, when present, is discussed. In the case of azithromycin, the presence of methanol leads to higher current peak values. However, in the case of Hemonlycin (R), methanol should be avoided because of its inhibiting influence on the qualitative and quantitative determination of ...azithromycin and on the azithromycin/lactose, separation.
TY - JOUR
AU - Avramov Ivić, Milka
AU - Petrović, Slobodan D.
AU - Mijin, Dušan
AU - Živković, Predrag M.
AU - Kosovic, IM
AU - Drjevic, KM
AU - Jovanović, Mica B.
PY - 2006
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/237
AB - The aim of the present study was to examine the oxidative properties and an assay of azithromycin and Hemomycin (R) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry. The maximum value of the current of the oxidation peak of pure azithromycin and azithromycin from Hemomycin (R) at 0.6 V versus SCE in 0.05 M NaHCO3 and in a mixture methanol -0.05 M NaHCO3 (1:1) at a scan rate of 50 mV s(-1) is a linear function of the concentration in the range of 0.235-0.588 mg/cm(3). HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the values of the current peak concerning the concentration of antibiotic in the investigated concentration range. The role of methanol, when present, is discussed. In the case of azithromycin, the presence of methanol leads to higher current peak values. However, in the case of Hemonlycin (R), methanol should be avoided because of its inhibiting influence on the qualitative and quantitative determination of azithromycin and on the azithromycin/lactose, separation.
PB - Oxford : Pergamon-Elsevier Science Ltd
T2 - Electrochimica Acta
T1 - Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte
VL - 51
IS - 12
SP - 2407
EP - 2416
DO - 10.1016/j.electacta.2005.07.032
ER -
@article{
author = "Avramov Ivić, Milka and Petrović, Slobodan D. and Mijin, Dušan and Živković, Predrag M. and Kosovic, IM and Drjevic, KM and Jovanović, Mica B.",
year = "2006",
abstract = "The aim of the present study was to examine the oxidative properties and an assay of azithromycin and Hemomycin (R) at a gold electrode in neutral electrolyte using cyclic linear sweep voltammetry. The maximum value of the current of the oxidation peak of pure azithromycin and azithromycin from Hemomycin (R) at 0.6 V versus SCE in 0.05 M NaHCO3 and in a mixture methanol -0.05 M NaHCO3 (1:1) at a scan rate of 50 mV s(-1) is a linear function of the concentration in the range of 0.235-0.588 mg/cm(3). HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the values of the current peak concerning the concentration of antibiotic in the investigated concentration range. The role of methanol, when present, is discussed. In the case of azithromycin, the presence of methanol leads to higher current peak values. However, in the case of Hemonlycin (R), methanol should be avoided because of its inhibiting influence on the qualitative and quantitative determination of azithromycin and on the azithromycin/lactose, separation.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte",
volume = "51",
number = "12",
pages = "2407-2416",
doi = "10.1016/j.electacta.2005.07.032"
}
Avramov Ivić, M., Petrović, S. D., Mijin, D., Živković, P. M., Kosovic, I., Drjevic, K.,& Jovanović, M. B.. (2006). Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 51(12), 2407-2416.
https://doi.org/10.1016/j.electacta.2005.07.032
Avramov Ivić M, Petrović SD, Mijin D, Živković PM, Kosovic I, Drjevic K, Jovanović MB. Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte. in Electrochimica Acta. 2006;51(12):2407-2416.
doi:10.1016/j.electacta.2005.07.032 .
Avramov Ivić, Milka, Petrović, Slobodan D., Mijin, Dušan, Živković, Predrag M., Kosovic, IM, Drjevic, KM, Jovanović, Mica B., "Studies on electrochemical oxidation of azithromycin and Hemomycin (R) at gold electrode in neutral electrolyte" in Electrochimica Acta, 51, no. 12 (2006):2407-2416,
https://doi.org/10.1016/j.electacta.2005.07.032 . .
