Show simple item record

dc.creatorStanojevic, Ana
dc.creatorMarković, Vladimir M.
dc.creatorČupić, Željko
dc.creatorKolar-Anić, Ljiljana
dc.creatorVukojevic, Vladana
dc.date.accessioned2019-01-30T17:59:01Z
dc.date.available2019-01-30T17:59:01Z
dc.date.issued2018
dc.identifier.issn2211-3398
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2365
dc.description.abstractStress is a physiological reaction of an organism to a demand for change that is imposed by external factors or is coming from within by way of physiological strains or self-perceived mental and/or emotional threats (internal factors). It manifests itself through the sudden release of a flood of hormones, including corticosteroids, into the blood, which rouse the body for action. Normally, stress is beneficial, but when lasting or being very strong, it causes major damage to our mind and body. Despite intense research, we still do not understand fully how the stress response axis, whose main function is to respond to challenges while maintaining the normal physiological balance, loses under prolonged exposure to stressors its capacity to maintain homeostasis. Recent applications of mathematical modelling and dynamical systems theory have enabled us to emulate complex neurochemical transformations that underlie the stress response, and help us to acquire deeper understanding of this dynamical regulatory network.en
dc.publisherElsevier Sci Ltd, Oxford
dc.relationSwedish Research Council - VR 2016-01922
dc.relationRajko and Maj Dermanovic Fund
dc.relationCMST COST Action Emergence and Evolution of Complex Chemical Systems - CM1304
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172015/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45001/RS//
dc.rightsrestrictedAccess
dc.sourceCurrent Opinion in Chemical Engineering
dc.titleAdvances in mathematical modelling of the hypothalamic-pituitary-adrenal (HPA) axis dynamics and the neuroendocrine response to stressen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанојевиц, Aна; Чупић, Жељко; Вукојевиц, Владана; Колар-Aниц, Љиљана; Марковиц, Владимир М.;
dc.citation.volume21
dc.citation.spage84
dc.citation.epage95
dc.citation.other21: 84-95
dc.citation.rankM21
dc.identifier.doi10.1016/j.coche.2018.04.003
dc.identifier.rcubConv_4034
dc.identifier.scopus2-s2.0-85046127842
dc.identifier.wos000452899100012
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record