Advances in mathematical modelling of the hypothalamic-pituitary-adrenal (HPA) axis dynamics and the neuroendocrine response to stress
Само за регистроване кориснике
2018
Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
Stress is a physiological reaction of an organism to a demand for change that is imposed by external factors or is coming from within by way of physiological strains or self-perceived mental and/or emotional threats (internal factors). It manifests itself through the sudden release of a flood of hormones, including corticosteroids, into the blood, which rouse the body for action. Normally, stress is beneficial, but when lasting or being very strong, it causes major damage to our mind and body. Despite intense research, we still do not understand fully how the stress response axis, whose main function is to respond to challenges while maintaining the normal physiological balance, loses under prolonged exposure to stressors its capacity to maintain homeostasis. Recent applications of mathematical modelling and dynamical systems theory have enabled us to emulate complex neurochemical transformations that underlie the stress response, and help us to acquire deeper understanding of this dyn...amical regulatory network.
Извор:
Current Opinion in Chemical Engineering, 2018, 21, 84-95Издавач:
- Elsevier Sci Ltd, Oxford
Финансирање / пројекти:
- Swedish Research Council - VR 2016-01922
- Rajko and Maj Dermanovic Fund
- CMST COST Action Emergence and Evolution of Complex Chemical Systems - CM1304
- Динамика нелинеарних физичкохемијских и биохемијских система са моделирањем и предвиђањем њихових понашања под неравнотежним условима (RS-172015)
- Наноструктурни функционални и композитни материјали у каталитичким и сорпционим процесима (RS-45001)
DOI: 10.1016/j.coche.2018.04.003
ISSN: 2211-3398
WoS: 000452899100012
Scopus: 2-s2.0-85046127842
Институција/група
IHTMTY - JOUR AU - Stanojevic, Ana AU - Marković, Vladimir M. AU - Čupić, Željko AU - Kolar-Anić, Ljiljana AU - Vukojevic, Vladana PY - 2018 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2365 AB - Stress is a physiological reaction of an organism to a demand for change that is imposed by external factors or is coming from within by way of physiological strains or self-perceived mental and/or emotional threats (internal factors). It manifests itself through the sudden release of a flood of hormones, including corticosteroids, into the blood, which rouse the body for action. Normally, stress is beneficial, but when lasting or being very strong, it causes major damage to our mind and body. Despite intense research, we still do not understand fully how the stress response axis, whose main function is to respond to challenges while maintaining the normal physiological balance, loses under prolonged exposure to stressors its capacity to maintain homeostasis. Recent applications of mathematical modelling and dynamical systems theory have enabled us to emulate complex neurochemical transformations that underlie the stress response, and help us to acquire deeper understanding of this dynamical regulatory network. PB - Elsevier Sci Ltd, Oxford T2 - Current Opinion in Chemical Engineering T1 - Advances in mathematical modelling of the hypothalamic-pituitary-adrenal (HPA) axis dynamics and the neuroendocrine response to stress VL - 21 SP - 84 EP - 95 DO - 10.1016/j.coche.2018.04.003 ER -
@article{ author = "Stanojevic, Ana and Marković, Vladimir M. and Čupić, Željko and Kolar-Anić, Ljiljana and Vukojevic, Vladana", year = "2018", abstract = "Stress is a physiological reaction of an organism to a demand for change that is imposed by external factors or is coming from within by way of physiological strains or self-perceived mental and/or emotional threats (internal factors). It manifests itself through the sudden release of a flood of hormones, including corticosteroids, into the blood, which rouse the body for action. Normally, stress is beneficial, but when lasting or being very strong, it causes major damage to our mind and body. Despite intense research, we still do not understand fully how the stress response axis, whose main function is to respond to challenges while maintaining the normal physiological balance, loses under prolonged exposure to stressors its capacity to maintain homeostasis. Recent applications of mathematical modelling and dynamical systems theory have enabled us to emulate complex neurochemical transformations that underlie the stress response, and help us to acquire deeper understanding of this dynamical regulatory network.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Current Opinion in Chemical Engineering", title = "Advances in mathematical modelling of the hypothalamic-pituitary-adrenal (HPA) axis dynamics and the neuroendocrine response to stress", volume = "21", pages = "84-95", doi = "10.1016/j.coche.2018.04.003" }
Stanojevic, A., Marković, V. M., Čupić, Ž., Kolar-Anić, L.,& Vukojevic, V.. (2018). Advances in mathematical modelling of the hypothalamic-pituitary-adrenal (HPA) axis dynamics and the neuroendocrine response to stress. in Current Opinion in Chemical Engineering Elsevier Sci Ltd, Oxford., 21, 84-95. https://doi.org/10.1016/j.coche.2018.04.003
Stanojevic A, Marković VM, Čupić Ž, Kolar-Anić L, Vukojevic V. Advances in mathematical modelling of the hypothalamic-pituitary-adrenal (HPA) axis dynamics and the neuroendocrine response to stress. in Current Opinion in Chemical Engineering. 2018;21:84-95. doi:10.1016/j.coche.2018.04.003 .
Stanojevic, Ana, Marković, Vladimir M., Čupić, Željko, Kolar-Anić, Ljiljana, Vukojevic, Vladana, "Advances in mathematical modelling of the hypothalamic-pituitary-adrenal (HPA) axis dynamics and the neuroendocrine response to stress" in Current Opinion in Chemical Engineering, 21 (2018):84-95, https://doi.org/10.1016/j.coche.2018.04.003 . .