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dc.creatorKrstić, Gordana
dc.creatorJadranin, Milka
dc.creatorTodorović, Nina
dc.creatorPešić, Milica
dc.creatorStankovic, Tijana
dc.creatorAljančić, Ivana
dc.creatorTešević, Vele
dc.date.accessioned2019-01-30T17:58:00Z
dc.date.available2019-01-30T17:58:00Z
dc.date.issued2018
dc.identifier.issn0031-9422
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2319
dc.description.abstractSeven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS//
dc.rightsrestrictedAccess
dc.sourcePhytochemistry
dc.subjectEuphorbia nicaeensisen
dc.subjectEuphorbiaceaeen
dc.subjectDiterpenoidsen
dc.subjectJatrophanesen
dc.subjectIsolationen
dc.subjectStructutre determinationen
dc.subjectP-glycoproteinen
dc.subjectMulti-drug resistanceen
dc.titleJatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанковиц, Тијана; Крстиц, Гордана; Јадранин, Милка; Тодоровић, Нина; Тесевиц, Веле В.; Песиц, Милица; Aљанчић, Ивана С.;
dc.citation.volume148
dc.citation.spage104
dc.citation.epage112
dc.citation.other148: 104-112
dc.citation.rankM21
dc.identifier.pmid29421506
dc.identifier.doi10.1016/j.phytochem.2018.01.016
dc.identifier.rcubConv_3892
dc.identifier.scopus2-s2.0-85041594265
dc.identifier.wos000427334600013
dc.type.versionpublishedVersion


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