ЦЕР - Централни Репозиторијум ИХТМ-а
Институт за хемију, технологију и металургију
    • English
    • Српски
    • Српски (Serbia)
  • Српски (ћирилица) 
    • Енглески
    • Српски (ћирилица)
    • Српски (латиница)
  • Пријава
Преглед записа 
  •   ЦЕР
  • IHTM
  • Radovi istraživača / Researchers' publications
  • Преглед записа
  •   ЦЕР
  • IHTM
  • Radovi istraživača / Researchers' publications
  • Преглед записа
JavaScript is disabled for your browser. Some features of this site may not work without it.

Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography

Thumbnail
2018
2269.pdf (273.7Kb)
Аутори
Savić, Jelena S.
Marković, Bojan
Vitnik, Vesna
Dilber, Sanda P.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
pKa values of five β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using the RP-HPLC method. Stationary phase was octadecyl modified (C-18) silica gel, and mobile phase was a mixture of methanol and one of nine different buffers (60:40, v/v). wspH values were measured after mixing methanol with an appropriate buffer. The mean retention time of each compound was plotted against wspH of each mobile phase. The inflection point of each sigmoidal curve represented wspK a of the compound. Using wspK a in already known equations for the specific methanol/buffer mixture, wwpK a values were calculated. Obtained pKa values for synthesized compounds were in a narrow range from 3.34-3.81 and pKa for ibuprofen was 4.45. Predicted pKa values for these compounds in SPARC software showed good correlation with experimental pKa values (R2=0.8048).
Кључне речи:
dissociation constant / anti-inflammatory compounds / ibuprofen / liquid chromatography
Извор:
Kragujevac Journal of Science, 2018, 40, 103-111
Издавач:
  • University of Kragujevac, Faculty of Science
Финансирање / пројекти:
  • Развој молекула са антиинфламаторним и кардиопроактивним дејством: структурне модификације, моделовање, физичкохемијска карактеризација и формулациона испитивања (RS-172041)

DOI: 10.5937/KgJSci1840103S

ISSN: 1450-9636

[ Google Scholar ]
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/2271
Колекције
  • Radovi istraživača / Researchers' publications
Институција/група
IHTM
TY  - JOUR
AU  - Savić, Jelena S.
AU  - Marković, Bojan
AU  - Vitnik, Vesna
AU  - Dilber, Sanda P.
PY  - 2018
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2271
AB  - pKa values of five β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using the RP-HPLC method. Stationary phase was octadecyl modified (C-18) silica gel, and mobile phase was a mixture of methanol and one of nine different buffers (60:40, v/v). wspH values were measured after mixing methanol with an appropriate buffer. The mean retention time of each compound was plotted against wspH of each mobile phase. The inflection point of each sigmoidal curve represented wspK a of the compound. Using wspK a in already known equations for the specific methanol/buffer mixture, wwpK a values were calculated. Obtained pKa values for synthesized compounds were in a narrow range from 3.34-3.81 and pKa for ibuprofen was 4.45. Predicted pKa values for these compounds in SPARC software showed good correlation with experimental pKa values (R2=0.8048).
PB  - University of Kragujevac, Faculty of Science
T2  - Kragujevac Journal of Science
T1  - Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography
IS  - 40
SP  - 103
EP  - 111
DO  - 10.5937/KgJSci1840103S
ER  - 
@article{
author = "Savić, Jelena S. and Marković, Bojan and Vitnik, Vesna and Dilber, Sanda P.",
year = "2018",
abstract = "pKa values of five β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using the RP-HPLC method. Stationary phase was octadecyl modified (C-18) silica gel, and mobile phase was a mixture of methanol and one of nine different buffers (60:40, v/v). wspH values were measured after mixing methanol with an appropriate buffer. The mean retention time of each compound was plotted against wspH of each mobile phase. The inflection point of each sigmoidal curve represented wspK a of the compound. Using wspK a in already known equations for the specific methanol/buffer mixture, wwpK a values were calculated. Obtained pKa values for synthesized compounds were in a narrow range from 3.34-3.81 and pKa for ibuprofen was 4.45. Predicted pKa values for these compounds in SPARC software showed good correlation with experimental pKa values (R2=0.8048).",
publisher = "University of Kragujevac, Faculty of Science",
journal = "Kragujevac Journal of Science",
title = "Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography",
number = "40",
pages = "103-111",
doi = "10.5937/KgJSci1840103S"
}
Savić, J. S., Marković, B., Vitnik, V.,& Dilber, S. P.. (2018). Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography. in Kragujevac Journal of Science
University of Kragujevac, Faculty of Science.(40), 103-111.
https://doi.org/10.5937/KgJSci1840103S
Savić JS, Marković B, Vitnik V, Dilber SP. Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography. in Kragujevac Journal of Science. 2018;(40):103-111.
doi:10.5937/KgJSci1840103S .
Savić, Jelena S., Marković, Bojan, Vitnik, Vesna, Dilber, Sanda P., "Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography" in Kragujevac Journal of Science, no. 40 (2018):103-111,
https://doi.org/10.5937/KgJSci1840103S . .

DSpace software copyright © 2002-2015  DuraSpace
О Централном репозиторијуму (ЦеР) | Пошаљите запажања

re3dataOpenAIRERCUB
 

 

Комплетан репозиторијумИнституције/групеАуториНасловиТемеОва институцијаАуториНасловиТеме

Статистика

Преглед статистика

DSpace software copyright © 2002-2015  DuraSpace
О Централном репозиторијуму (ЦеР) | Пошаљите запажања

re3dataOpenAIRERCUB