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dc.creatorAbulseoud, Osama A.
dc.creatorHo, Man Choi
dc.creatorChoi, Doo-Sup
dc.creatorStanojevic, Ana
dc.creatorČupić, Željko
dc.creatorKolar-Anić, Ljiljana
dc.creatorVukojevic, Vladana
dc.date.accessioned2019-01-30T17:56:55Z
dc.date.available2019-01-30T17:56:55Z
dc.date.issued2017
dc.identifier.issn1932-6203
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2269
dc.description.abstractChanges in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled (LHK) rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK. Synergistic combination of the LHK rat model and dynamical systems theory allows us to quantitatively characterize changes in HPA axis activity under controlled induction of acute manic-like states and provides a framework to study in silico how the dynamic integration of neurochemical transformations underlying the HPA axis is disrupted in these states.en
dc.publisherPublic Library of Science (PLoS)
dc.relationKI-Mayo research
dc.relationSwedish Research Council
dc.relationKnut and Alice Wallenberg Foundation
dc.relationRajko and Maj DermanoviC Fund
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172015/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45001/RS//
dc.relationCMST COST Action CM1304 "Emergence and Evolution of Complex Chemical Systems"
dc.rightsopenAccess
dc.sourcePlos One
dc.titleCorticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modelingen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractAбулсеоуд, Осама A.; Хо, Ман Цхои; Цхои, Доо-Суп; Чупић, Жељко; Станојевиц, Aна; Вукојевиц, Владана; Колар-Aниц, Љиљана;
dc.citation.volume12
dc.citation.issue5
dc.citation.other12(5):
dc.citation.rankM21
dc.identifier.pmid28542167
dc.identifier.doi10.1371/journal.pone.0177551
dc.identifier.rcubConv_3726
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8662/2267.pdf
dc.identifier.scopus2-s2.0-85019566700
dc.identifier.wos000401672400053
dc.type.versionpublishedVersion


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