Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling

2017
Authors
Abulseoud, Osama A.Ho, Man Choi
Choi, Doo-Sup
Stanojevic, Ana

Čupić, Željko

Kolar-Anić, Ljiljana

Vukojevic, Vladana

Article (Published version)
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Show full item recordAbstract
Changes in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled (LHK) rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK. Synergistic combination of the LHK rat model and dynamical systems theory allows us to quantitatively characterize changes in HPA axis activity under controlled induction of acute manic-like states and provides a framework to study in silico how the dynamic integration of neurochemical transformations underlying the HPA axis is disrupted in these states.
Source:
Plos One, 2017, 12, 5Publisher:
- Public Library of Science (PLoS)
Funding / projects:
- KI-Mayo research
- Swedish Research Council
- Knut and Alice Wallenberg Foundation
- Rajko and Maj DermanoviC Fund
- Dynamics of nonlinear physicochemical and biochemical systems with modeling and predicting of their behavior under nonequilibrium conditions (RS-172015)
- Nanostructured Functional and Composite Materials in Catalytic and Sorption Processes (RS-45001)
- CMST COST Action CM1304 "Emergence and Evolution of Complex Chemical Systems"
DOI: 10.1371/journal.pone.0177551
ISSN: 1932-6203
PubMed: 28542167
WoS: 000401672400053
Scopus: 2-s2.0-85019566700
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IHTMTY - JOUR AU - Abulseoud, Osama A. AU - Ho, Man Choi AU - Choi, Doo-Sup AU - Stanojevic, Ana AU - Čupić, Željko AU - Kolar-Anić, Ljiljana AU - Vukojevic, Vladana PY - 2017 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2269 AB - Changes in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled (LHK) rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK. Synergistic combination of the LHK rat model and dynamical systems theory allows us to quantitatively characterize changes in HPA axis activity under controlled induction of acute manic-like states and provides a framework to study in silico how the dynamic integration of neurochemical transformations underlying the HPA axis is disrupted in these states. PB - Public Library of Science (PLoS) T2 - Plos One T1 - Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling VL - 12 IS - 5 DO - 10.1371/journal.pone.0177551 ER -
@article{ author = "Abulseoud, Osama A. and Ho, Man Choi and Choi, Doo-Sup and Stanojevic, Ana and Čupić, Željko and Kolar-Anić, Ljiljana and Vukojevic, Vladana", year = "2017", abstract = "Changes in the hypothalamic-pituitary-adrenal (HPA) axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled (LHK) rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK. Synergistic combination of the LHK rat model and dynamical systems theory allows us to quantitatively characterize changes in HPA axis activity under controlled induction of acute manic-like states and provides a framework to study in silico how the dynamic integration of neurochemical transformations underlying the HPA axis is disrupted in these states.", publisher = "Public Library of Science (PLoS)", journal = "Plos One", title = "Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling", volume = "12", number = "5", doi = "10.1371/journal.pone.0177551" }
Abulseoud, O. A., Ho, M. C., Choi, D., Stanojevic, A., Čupić, Ž., Kolar-Anić, L.,& Vukojevic, V.. (2017). Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling. in Plos One Public Library of Science (PLoS)., 12(5). https://doi.org/10.1371/journal.pone.0177551
Abulseoud OA, Ho MC, Choi D, Stanojevic A, Čupić Ž, Kolar-Anić L, Vukojevic V. Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling. in Plos One. 2017;12(5). doi:10.1371/journal.pone.0177551 .
Abulseoud, Osama A., Ho, Man Choi, Choi, Doo-Sup, Stanojevic, Ana, Čupić, Željko, Kolar-Anić, Ljiljana, Vukojevic, Vladana, "Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat-Experimental observations and mathematical modeling" in Plos One, 12, no. 5 (2017), https://doi.org/10.1371/journal.pone.0177551 . .