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Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile
dc.creator | Stanojevic, A. | |
dc.creator | Markovic, V. M. | |
dc.creator | Čupić, Željko | |
dc.creator | Vukojevic, V. | |
dc.creator | Kolar-Anić, Ljiljana | |
dc.date.accessioned | 2019-01-30T17:56:35Z | |
dc.date.available | 2019-01-30T17:56:35Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0036-0244 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2254 | |
dc.description.abstract | A model was developed that can be used to study the effect of gradual cholesterol intake by food on the HPA axis dynamics. Namely, well defined oscillatory dynamics of vital neuroendocrine hypothalamic-pituitary-adrenal (HPA) axis has proven to be necessary for maintaining regular basal physiology and formulating appropriate stress response to various types of perturbations. Cholesterol, as a precursor of all steroid HPA axis hormones, can alter the dynamics of HPA axis. To analyse its particular influence on the HPA axis dynamics we used stoichiometric model of HPA axis activity, and simulate cholesterol perturbations in the form of finite duration pulses, with asymmetrically distributed concentration profile. Our numerical simulations showed that there is a complex, nonlinear dependence between the HPA axis responsiveness and different forms of applied cholesterol concentration pulses, indicating the significance of kinetic modelling, and dynamical systems theory for the understanding of large-scale self-regulatory, and homeostatic processes within this neuroendocrine system. | en |
dc.publisher | Maik Nauka/Interperiodica/Springer, New York | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172015/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45001/RS// | |
dc.relation | CMST COST Action Emergence and Evolution of Complex Chemical Systems - CM1304 | |
dc.relation | Karolinska Institute Research Funds | |
dc.relation | Swedish Research Council | |
dc.rights | restrictedAccess | |
dc.source | Russian Journal of Physical Chemistry A | |
dc.subject | oscillatory processes | en |
dc.subject | kinetics of complex reaction systems | en |
dc.subject | nonlinear dynamics | en |
dc.subject | modelling of cholesterol perturbations | en |
dc.subject | hypothalamic | en |
dc.subject | pituitary-adrenal axis | en |
dc.subject | statins | en |
dc.title | Modelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profile | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вукојевиц, В.; Марковиц, В. М.; Станојевиц, A.; Колар-Aниц, Л.; Чупић, Жељко; | |
dc.citation.volume | 91 | |
dc.citation.issue | 13 | |
dc.citation.spage | 2600 | |
dc.citation.epage | 2607 | |
dc.citation.other | 91(13): 2600-2607 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.1134/S0036024417130027 | |
dc.identifier.scopus | 2-s2.0-85040143595 | |
dc.identifier.wos | 000425149900016 | |
dc.type.version | publishedVersion |