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dc.creatorStanojevic, A.
dc.creatorMarkovic, V. M.
dc.creatorČupić, Željko
dc.creatorVukojevic, V.
dc.creatorKolar-Anić, Ljiljana
dc.date.accessioned2019-01-30T17:56:35Z
dc.date.available2019-01-30T17:56:35Z
dc.date.issued2017
dc.identifier.issn0036-0244
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2254
dc.description.abstractA model was developed that can be used to study the effect of gradual cholesterol intake by food on the HPA axis dynamics. Namely, well defined oscillatory dynamics of vital neuroendocrine hypothalamic-pituitary-adrenal (HPA) axis has proven to be necessary for maintaining regular basal physiology and formulating appropriate stress response to various types of perturbations. Cholesterol, as a precursor of all steroid HPA axis hormones, can alter the dynamics of HPA axis. To analyse its particular influence on the HPA axis dynamics we used stoichiometric model of HPA axis activity, and simulate cholesterol perturbations in the form of finite duration pulses, with asymmetrically distributed concentration profile. Our numerical simulations showed that there is a complex, nonlinear dependence between the HPA axis responsiveness and different forms of applied cholesterol concentration pulses, indicating the significance of kinetic modelling, and dynamical systems theory for the understanding of large-scale self-regulatory, and homeostatic processes within this neuroendocrine system.en
dc.publisherMaik Nauka/Interperiodica/Springer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172015/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45001/RS//
dc.relationCMST COST Action Emergence and Evolution of Complex Chemical Systems - CM1304
dc.relationKarolinska Institute Research Funds
dc.relationSwedish Research Council
dc.rightsrestrictedAccess
dc.sourceRussian Journal of Physical Chemistry A
dc.subjectoscillatory processesen
dc.subjectkinetics of complex reaction systemsen
dc.subjectnonlinear dynamicsen
dc.subjectmodelling of cholesterol perturbationsen
dc.subjecthypothalamicen
dc.subjectpituitary-adrenal axisen
dc.subjectstatinsen
dc.titleModelling of the Hypothalamic-Pituitary-Adrenal Axis Perturbations by Externally Induced Cholesterol Pulses of Finite Duration and with Asymmetrically Distributed Concentration Profileen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВукојевиц, В.; Марковиц, В. М.; Станојевиц, A.; Колар-Aниц, Л.; Чупић, Жељко;
dc.citation.volume91
dc.citation.issue13
dc.citation.spage2600
dc.citation.epage2607
dc.citation.other91(13): 2600-2607
dc.citation.rankM23
dc.identifier.doi10.1134/S0036024417130027
dc.identifier.rcubConv_3874
dc.identifier.scopus2-s2.0-85040143595
dc.identifier.wos000425149900016
dc.type.versionpublishedVersion


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