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Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark
dc.creator | Novaković, Miroslav | |
dc.creator | Nikodinović-Runić, Jasmina | |
dc.creator | Veselinović, Jovana | |
dc.creator | Ilić-Tomić, Tatjana | |
dc.creator | Vidaković, Vera | |
dc.creator | Tešević, Vele | |
dc.creator | Milosavljević, Slobodan | |
dc.date.accessioned | 2019-01-30T17:56:14Z | |
dc.date.available | 2019-01-30T17:56:14Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2237 | |
dc.description.abstract | Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation. | en |
dc.publisher | American Chemical Society (ACS) | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173048/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Natural Products | |
dc.title | Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Новаковић, Мирослав; Веселиновиц, Јована; Милосављевиц, Слободан; Илиц-Томиц, Татјана; Никодиновиц-Руниц, Јасмина; Видаковиц, Вера; Тесевиц, Веле; | |
dc.citation.volume | 80 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1255 | |
dc.citation.epage | 1263 | |
dc.citation.other | 80(5): 1255-1263 | |
dc.citation.rank | aM21 | |
dc.identifier.pmid | 28368586 | |
dc.identifier.doi | 10.1021/acs.jnatprod.6b00805 | |
dc.identifier.scopus | 2-s2.0-85019767389 | |
dc.identifier.wos | 000402498300004 | |
dc.type.version | publishedVersion |