Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark
Само за регистроване кориснике
2017
Аутори
Novaković, Miroslav
Nikodinović-Runić, Jasmina

Veselinović, Jovana
Ilić-Tomić, Tatjana

Vidaković, Vera

Tešević, Vele

Milosavljević, Slobodan

Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation.
Извор:
Journal of Natural Products, 2017, 80, 5, 1255-1263Издавач:
- American Chemical Society (ACS)
Финансирање / пројекти:
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-172053)
- Изучавање микробиолошког диверзитета и карактеризација корисних срединских микроорганизама (RS-173048)
DOI: 10.1021/acs.jnatprod.6b00805
ISSN: 0163-3864
PubMed: 28368586
WoS: 000402498300004
Scopus: 2-s2.0-85019767389
Институција/група
IHTMTY - JOUR AU - Novaković, Miroslav AU - Nikodinović-Runić, Jasmina AU - Veselinović, Jovana AU - Ilić-Tomić, Tatjana AU - Vidaković, Vera AU - Tešević, Vele AU - Milosavljević, Slobodan PY - 2017 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2237 AB - Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation. PB - American Chemical Society (ACS) T2 - Journal of Natural Products T1 - Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark VL - 80 IS - 5 SP - 1255 EP - 1263 DO - 10.1021/acs.jnatprod.6b00805 ER -
@article{ author = "Novaković, Miroslav and Nikodinović-Runić, Jasmina and Veselinović, Jovana and Ilić-Tomić, Tatjana and Vidaković, Vera and Tešević, Vele and Milosavljević, Slobodan", year = "2017", abstract = "Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation.", publisher = "American Chemical Society (ACS)", journal = "Journal of Natural Products", title = "Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark", volume = "80", number = "5", pages = "1255-1263", doi = "10.1021/acs.jnatprod.6b00805" }
Novaković, M., Nikodinović-Runić, J., Veselinović, J., Ilić-Tomić, T., Vidaković, V., Tešević, V.,& Milosavljević, S.. (2017). Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark. in Journal of Natural Products American Chemical Society (ACS)., 80(5), 1255-1263. https://doi.org/10.1021/acs.jnatprod.6b00805
Novaković M, Nikodinović-Runić J, Veselinović J, Ilić-Tomić T, Vidaković V, Tešević V, Milosavljević S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark. in Journal of Natural Products. 2017;80(5):1255-1263. doi:10.1021/acs.jnatprod.6b00805 .
Novaković, Miroslav, Nikodinović-Runić, Jasmina, Veselinović, Jovana, Ilić-Tomić, Tatjana, Vidaković, Vera, Tešević, Vele, Milosavljević, Slobodan, "Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark" in Journal of Natural Products, 80, no. 5 (2017):1255-1263, https://doi.org/10.1021/acs.jnatprod.6b00805 . .