The electrodegradation of azithromycin was studied by its indirect oxidation using dimensionally stable Ti/RuO2 anode as catalyst in the electrolyte containing methanol, 0.05 M NaHCO3, sodium chloride and deionized water. The optimal conditions for galvanostatic electrodegradation for the azithromycin concentration of 0.472 mg cm(-3) were found to be NaCl concentration of 7 mg cm(-3) and the applied current of 300 mA. The differential pulse voltammetry using glassy carbon electrode was performed for the first time in the above-mentioned content of electrolyte for the nine concentration of azithromycin (0.075-0.675 mg cm(-3)) giving the limits of azithromycin detection and of quantification as: LOD 0.044 mg cm(-3) and LOQ 0.145 mg cm(-3). The calibration curve was constructed enabling the electrolyte analysis during its electrodegradation process. The electrolyte was analyzed by high-performance liquid chromatography and electrospray ionization time-of-flight mass spectrometry. The elec...trooxidation products were identified and after 180 min there was no azithromycin in the electrolyte while TOC analysis showed that 79% of azithromycin was mineralized. The proposed degradation scheme is presented.
TY - JOUR
AU - Radosavljevic, Kristina D.
AU - Lović, Jelena
AU - Mijin, Dušan
AU - Petrović, Slobodan D.
AU - Jadranin, Milka
AU - Mladenović, Aleksandar R.
AU - Avramov Ivić, Milka
PY - 2017
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2233
AB - The electrodegradation of azithromycin was studied by its indirect oxidation using dimensionally stable Ti/RuO2 anode as catalyst in the electrolyte containing methanol, 0.05 M NaHCO3, sodium chloride and deionized water. The optimal conditions for galvanostatic electrodegradation for the azithromycin concentration of 0.472 mg cm(-3) were found to be NaCl concentration of 7 mg cm(-3) and the applied current of 300 mA. The differential pulse voltammetry using glassy carbon electrode was performed for the first time in the above-mentioned content of electrolyte for the nine concentration of azithromycin (0.075-0.675 mg cm(-3)) giving the limits of azithromycin detection and of quantification as: LOD 0.044 mg cm(-3) and LOQ 0.145 mg cm(-3). The calibration curve was constructed enabling the electrolyte analysis during its electrodegradation process. The electrolyte was analyzed by high-performance liquid chromatography and electrospray ionization time-of-flight mass spectrometry. The electrooxidation products were identified and after 180 min there was no azithromycin in the electrolyte while TOC analysis showed that 79% of azithromycin was mineralized. The proposed degradation scheme is presented.
PB - Versita, Warsaw
T2 - Chemical Papers
T1 - Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis
VL - 71
IS - 7
SP - 1217
EP - 1224
DO - 10.1007/s11696-016-0115-2
ER -
@article{
author = "Radosavljevic, Kristina D. and Lović, Jelena and Mijin, Dušan and Petrović, Slobodan D. and Jadranin, Milka and Mladenović, Aleksandar R. and Avramov Ivić, Milka",
year = "2017",
abstract = "The electrodegradation of azithromycin was studied by its indirect oxidation using dimensionally stable Ti/RuO2 anode as catalyst in the electrolyte containing methanol, 0.05 M NaHCO3, sodium chloride and deionized water. The optimal conditions for galvanostatic electrodegradation for the azithromycin concentration of 0.472 mg cm(-3) were found to be NaCl concentration of 7 mg cm(-3) and the applied current of 300 mA. The differential pulse voltammetry using glassy carbon electrode was performed for the first time in the above-mentioned content of electrolyte for the nine concentration of azithromycin (0.075-0.675 mg cm(-3)) giving the limits of azithromycin detection and of quantification as: LOD 0.044 mg cm(-3) and LOQ 0.145 mg cm(-3). The calibration curve was constructed enabling the electrolyte analysis during its electrodegradation process. The electrolyte was analyzed by high-performance liquid chromatography and electrospray ionization time-of-flight mass spectrometry. The electrooxidation products were identified and after 180 min there was no azithromycin in the electrolyte while TOC analysis showed that 79% of azithromycin was mineralized. The proposed degradation scheme is presented.",
publisher = "Versita, Warsaw",
journal = "Chemical Papers",
title = "Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis",
volume = "71",
number = "7",
pages = "1217-1224",
doi = "10.1007/s11696-016-0115-2"
}
Radosavljevic, K. D., Lović, J., Mijin, D., Petrović, S. D., Jadranin, M., Mladenović, A. R.,& Avramov Ivić, M.. (2017). Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis. in Chemical Papers
Versita, Warsaw., 71(7), 1217-1224.
https://doi.org/10.1007/s11696-016-0115-2
Radosavljevic KD, Lović J, Mijin D, Petrović SD, Jadranin M, Mladenović AR, Avramov Ivić M. Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis. in Chemical Papers. 2017;71(7):1217-1224.
doi:10.1007/s11696-016-0115-2 .
Radosavljevic, Kristina D., Lović, Jelena, Mijin, Dušan, Petrović, Slobodan D., Jadranin, Milka, Mladenović, Aleksandar R., Avramov Ivić, Milka, "Degradation of azithromycin using Ti/RuO2 anode as catalyst followed by DPV, HPLC-UV and MS analysis" in Chemical Papers, 71, no. 7 (2017):1217-1224,
https://doi.org/10.1007/s11696-016-0115-2 . .
