The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity

Pejin, Boris; Tešanović, K.; Jakovljević, Dragica; Kaišarević, S.; Šibul, F.; Rašeta, M.; Karaman, M.

doi:10.1080/14786419.2017.1405417

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2017

Authors

Pejin, Boris

Tešanović, K.
Jakovljević, Dragica

Kaišarević, S.
Šibul, F.
Rašeta, M.
Karaman, M.

Article (Published version)

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Abstract

The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.

Keywords:

AChE inhibitors of natural origin not belonging to the alkaloids / Alzheimer’s disease / Mushrooms / sugars

Source:
Natural Product Research, 2017, 1-5

Publisher:

Taylor and Francis Ltd.

Funding / projects:

DOI: 10.1080/14786419.2017.1405417

ISSN: 1478-6419

WoS: 000466416500021

Scopus: 2-s2.0-85034782445

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TY  - JOUR
AU  - Pejin, Boris
AU  - Tešanović, K.
AU  - Jakovljević, Dragica
AU  - Kaišarević, S.
AU  - Šibul, F.
AU  - Rašeta, M.
AU  - Karaman, M.
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2226
AB  - The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.
PB  - Taylor and Francis Ltd.
T2  - Natural Product Research
T1  - The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity
SP  - 1
EP  - 5
DO  - 10.1080/14786419.2017.1405417
ER  -

@article{
author = "Pejin, Boris and Tešanović, K. and Jakovljević, Dragica and Kaišarević, S. and Šibul, F. and Rašeta, M. and Karaman, M.",
year = "2017",
abstract = "The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.",
publisher = "Taylor and Francis Ltd.",
journal = "Natural Product Research",
title = "The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity",
pages = "1-5",
doi = "10.1080/14786419.2017.1405417"
}

Pejin, B., Tešanović, K., Jakovljević, D., Kaišarević, S., Šibul, F., Rašeta, M.,& Karaman, M.. (2017). The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity. in Natural Product Research
Taylor and Francis Ltd.., 1-5.
https://doi.org/10.1080/14786419.2017.1405417

Pejin B, Tešanović K, Jakovljević D, Kaišarević S, Šibul F, Rašeta M, Karaman M. The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity. in Natural Product Research. 2017;:1-5.
doi:10.1080/14786419.2017.1405417 .

Pejin, Boris, Tešanović, K., Jakovljević, Dragica, Kaišarević, S., Šibul, F., Rašeta, M., Karaman, M., "The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity" in Natural Product Research (2017):1-5,
https://doi.org/10.1080/14786419.2017.1405417 . .