Show simple item record

dc.creatorIlić-Tomić, Tatjana
dc.creatorSoković, Marina
dc.creatorVojnovic, Sandra
dc.creatorCiric, Ana
dc.creatorVeljić, Milan
dc.creatorNikodinović-Runić, Jasmina
dc.creatorNovaković, Miroslav
dc.date.accessioned2019-01-30T17:55:28Z
dc.date.available2019-01-30T17:55:28Z
dc.date.issued2017
dc.identifier.issn0032-0943
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2199
dc.description.abstractDiarylheptanoids from the barks of Alnus viridis ssp. viridis (green alder) and Alnus glutinosa (black alder) were explored for anti-quorum sensing activity. Chemicals with anti-quorum sensing activity have recently been examined for antimicrobial applications. The anti-quorum sensing activity of the selected diarylheptanoids was determined using two biosensors, namely Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum CV026. Although all of the investigated compounds negatively influenced the motility of P. aeruginosa PAO1, four were able to inhibit biofilm formation of this human opportunistic pathogen for 40-70%. Three of the diarylheptanoids (3, 4, and 5) negatively influenced the biosynthesis of pyocyanin, which is under the control of quorum sensing. Platyphyllenone (7) and hirsutenone (5) were able to inhibit the biosynthesis of violacein in C. violaceum CV026, with 5 being able to inhibit the synthesis of both biopigments. Only one of the tested diarylheptanoids (1) was shown to significantly decrease the production of acyl homoserine lactones (AHL) in P. aeruginosa PAO1, more specifically, production of the long chain N-(3-oxododecanoyl)- l-HSL. On the other side, four diarylheptanoids (2-5) significantly reduced the synthesis of 2-alkyl-4-quinolones, part of the P. aeruginosa quinolone-mediated signaling system. To properly assess therapeutic potential of these compounds, their in vitro antiproliferative effect on normal human lung fibroblasts was determined, with doses affecting cell proliferation between 10 and 100 mu g/mL. This study confirms that the barks of green and black alders are rich source of phytochemicals with a wide range of biological activities that could further be exploited as natural agents against bacterial contaminations and infections.en
dc.publisherGeorg Thieme Verlag Kg, Stuttgart
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173048/RS//
dc.rightsrestrictedAccess
dc.sourcePlanta Medica
dc.subjectAlnus viridis ssp viridisen
dc.subjectAlnus glutinosaen
dc.subjectBetulaceaeen
dc.subjectdiarylheptanoidsen
dc.subjectquorum sensingen
dc.subjectacyl homoserine lactoneen
dc.subjectPseudomonas aeruginosaen
dc.titleDiarylheptanoids from Alnus viridis ssp viridis and Alnus glutinosa: Modulation of Quorum Sensing Activity in Pseudomonas aeruginosaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦириц, Aна; Новаковић, Мирослав; Никодиновиц-Руниц, Јасмина; Војновиц, Сандра; Соковиц, Марина; Вељиц, Милан; Илиц-Томиц, Татјана;
dc.citation.volume83
dc.citation.issue01-02
dc.citation.spage117
dc.citation.epage125
dc.citation.other83(01-02): 117-125
dc.citation.rankM21
dc.identifier.pmid27220074
dc.identifier.doi10.1055/s-0042-107674
dc.identifier.rcubConv_3672
dc.identifier.scopus2-s2.0-84969933386
dc.identifier.wos000393182100015
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record