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dc.creatorCetenovic, Bojana
dc.creatorProkic, Bogomir
dc.creatorVasilijic, Sasa
dc.creatorDojčinović, Biljana
dc.creatorMagic, Marko
dc.creatorJokanovic, Vukoman
dc.creatorMarković, Dejan
dc.date.accessioned2019-01-30T17:55:16Z
dc.date.available2019-01-30T17:55:16Z
dc.date.issued2017
dc.identifier.issn0099-2399
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2186
dc.description.abstractIntroduction: The aim of this article was to analyze biocompatibility and bioactivity of new endodontic materials on the basis of nanosynthesized calcium silicates (ALBO-MPCA(1) and ALBO-MPCA(2)) combined with different radiopacifiers in comparison with MTA(+). Methods: Morphology of the samples was studied by scanning electron microscopy, and the pH and ion release analysis were also assessed. Biocompatibility of materials' eluates (24-hour, 7-day, and 21-day) was conducted by using MIT test. Twelve New Zealand white rabbits were used for intraosseous implantation. Four calvarial defects per animal were created and filled with freshly prepared investigated materials. Results: Samples mostly consisted of agglomerates built up from nanoparticles, preferably spherical and rod-like. There was no significant difference among pH values of materials' eluates after 24 hours (P>.05). The amount of calcium and aluminum ion release decreased, whereas the amount of magnesium and bismuth (ALBO-MPCAl, MTA(+)) and barium (ALBO-MPCA(2)) increased during 21-day period. The metabolic activity of cells increased after the extraction time, except in case of undiluted elutes of ALBO-MPCA(2) and ALBO-MPCAI (21-day). Histologic analysis of the samples revealed newly formed bone tissue with moderate inflammation for all investigated materials, which subsided during 90-day period to mild. Both MIA(+) and ALBO-MPCAI were in direct contact with the newly formed bone tissue. After 90 days, statistically significant difference in hard tissue formation was observed in comparison of MIA(+) and ALBO-MPCki with control group (P LT .05). Conclusions: Experimental materials ALBOMPCA, and ALBO-MPCA(2) possess both biocompatibility and bioactivity. Because ALBO-MPCAA provokes favorable biological response, it is especially good candidate for further clinical investigations.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Endodontics
dc.subjectBiocompatibilityen
dc.subjectbiomaterialsen
dc.subjectcalcium silicatesen
dc.subjectintraosseous implantationen
dc.subjectMTAen
dc.subjectMITen
dc.titleBiocompatibility Investigation of New Endodontic Materials Based on Nanosynthesized Calcium Silicates Combined with Different Radiopacifiersen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВасилијиц, Саса; Цетеновиц, Бојана; Дојчиновић, Биљана; Марковиц, Дејан; Магиц, Марко; Прокиц, Богомир; Јокановиц, Вукоман;
dc.citation.volume43
dc.citation.issue3
dc.citation.spage425
dc.citation.epage432
dc.citation.other43(3): 425-432
dc.citation.rankM21
dc.identifier.pmid28231981
dc.identifier.doi10.1016/j.joen.2016.10.041
dc.identifier.rcubConv_3688
dc.identifier.scopus2-s2.0-85013350258
dc.identifier.wos000395971900011
dc.type.versionpublishedVersion


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