Antibacterial and antifungal properties of guanylhydrazones
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A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities against Staphylococcus aureus ATCC 25923 and Micrococcus luteus ATCC 379 with minimal inhibitory concentrations of 4 ae g mL(-1), and good antifungal activity against Candida parapsilosis ATCC 22019. These results suggested that the selected guanylhydrazones could serve as promising leads for improved antimicrobial development.
Keywords:guanylhydrazones / iminoguanidines / antibacterial activity / antifungal activity / Candida spp.
Source:Journal of the Serbian Chemical Society, 2017, 82, 6, 641-649
- Serbian Chemical Soc, Belgrade
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