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dc.creatorZmejkovski, Bojana
dc.creatorPantelic, Nebojsa
dc.creatorFilipovic, Lana
dc.creatorArandelovic, Sandra
dc.creatorRadulovic, Sinisa
dc.creatorSabo, Tibor
dc.creatorKaluđerović, Goran N.
dc.date.accessioned2019-01-30T17:54:06Z
dc.date.available2019-01-30T17:54:06Z
dc.date.issued2017
dc.identifier.issn1871-5206
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2132
dc.description.abstractAims: Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)(2)eddip}] (n = 2, 4: 1, 2, respectively; (S,S)-(i-Am)(2)eddip = O,O'-diisoamyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate) were synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Method: Quantum chemical calculations were used to predict formed isomers of 1 and 2. Furthermore, reduction of 2 with ascorbic acid was followed by time-dependant C-13 NMR spectroscopy in order to enable assignation of the formed isomers for complex 1. In vitro cytotoxic activity was determined for 1 and 2 on a panel of five human tumor cell lines derived from cervix adenocarcinoma (HeLa), alveolar basal adenocarcinoma (A549), breast adenocarcinoma (MDA-453), colorectal cancer (LS 174), erythromyeloblastoid leukemia (K562), as well as one non-malignant human lung fibroblast cell line (MRC-5), using MTT assay. Result: Both complexes exhibited high (2 against K562: IC50 = 5.4 mu M), more active than cisplatin, to moderate activity (1). Both complexes caused considerable decrease of cell number in K562 cells in G1, S and G2 phases, concordantly increasing subpopulation in sub-G1 fraction. Morphological analysis of K562 cell death induced by platinum(II/IV) complexes indicate apoptosis.en
dc.publisherBentham Science Publ Ltd, Sharjah
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.rightsrestrictedAccess
dc.sourceAnti-Cancer Agents in Medicinal Chemistry
dc.subjectPlatinum complexesen
dc.subjectR(2)eddip ligandsen
dc.subjectDFT calculationsen
dc.subjectanticancer activityen
dc.subjectapoptosisen
dc.subjectcell cycleen
dc.titleIn Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Aciden
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЗмејковски, Бојана; Пантелиц, Небојса; Филиповиц, Лана; Aранделовиц, Сандра; Радуловиц, Синиса; Калудеровиц, Горан Н.; Сабо, Тибор Ј.;
dc.citation.volume17
dc.citation.issue8
dc.citation.spage1136
dc.citation.epage1143
dc.citation.other17(8): 1136-1143
dc.citation.rankM22
dc.identifier.pmid27928952
dc.identifier.doi10.2174/1871520616666161207155634
dc.identifier.rcubConv_3767
dc.identifier.scopus2-s2.0-85027877786
dc.identifier.wos000407271800011
dc.type.versionpublishedVersion


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