Synthesis, antioxidant and antimicrobial activity of carbohydrazones
2017
Аутори
Božić, Aleksandra R.Filipovic, Nenad R.
Novaković, Irena
Bjelogrlić, Snežana K.
Nikolić, Jasmina B.
Drmanić, Saša Ž.
Marinković, Aleksandar D.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide-water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone.
Кључне речи:
carbohydrazones / antibacterial / antifungal / antioxidant activity / isomersИзвор:
Journal of the Serbian Chemical Society, 2017, 82, 5, 495-508Издавач:
- Serbian Chemical Society
Финансирање / пројекти:
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-MESTD-Basic Research (BR or ON)-172013)
DOI: 10.2298/JSC161220045B
ISSN: 0352-5139
WoS: 000408085400003
Scopus: 2-s2.0-85021727647
Институција/група
IHTMTY - JOUR AU - Božić, Aleksandra R. AU - Filipovic, Nenad R. AU - Novaković, Irena AU - Bjelogrlić, Snežana K. AU - Nikolić, Jasmina B. AU - Drmanić, Saša Ž. AU - Marinković, Aleksandar D. PY - 2017 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2130 AB - Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide-water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone. PB - Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - Synthesis, antioxidant and antimicrobial activity of carbohydrazones VL - 82 IS - 5 SP - 495 EP - 508 DO - 10.2298/JSC161220045B ER -
@article{ author = "Božić, Aleksandra R. and Filipovic, Nenad R. and Novaković, Irena and Bjelogrlić, Snežana K. and Nikolić, Jasmina B. and Drmanić, Saša Ž. and Marinković, Aleksandar D.", year = "2017", abstract = "Fourteen mono- and bis-carbohydrazone ligands have been synthesized and characterized. Antioxidant activity of the substances was investigated together with possible (E)/(Z) isomerization, and explained on the most active antioxidant compound 4 in various dimethyl sulphoxide-water mixtures. The addition of water to the system was involved in the formation of hydrated molecules which was confirmed in NMR after the addition of D2O. The ligands were tested in vitro against Gram-positive and Gram-negative bacteria and fungi, and their activity was discussed in relation to the structure of investigated carbohydrazone.", publisher = "Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "Synthesis, antioxidant and antimicrobial activity of carbohydrazones", volume = "82", number = "5", pages = "495-508", doi = "10.2298/JSC161220045B" }
Božić, A. R., Filipovic, N. R., Novaković, I., Bjelogrlić, S. K., Nikolić, J. B., Drmanić, S. Ž.,& Marinković, A. D.. (2017). Synthesis, antioxidant and antimicrobial activity of carbohydrazones. in Journal of the Serbian Chemical Society Serbian Chemical Society., 82(5), 495-508. https://doi.org/10.2298/JSC161220045B
Božić AR, Filipovic NR, Novaković I, Bjelogrlić SK, Nikolić JB, Drmanić SŽ, Marinković AD. Synthesis, antioxidant and antimicrobial activity of carbohydrazones. in Journal of the Serbian Chemical Society. 2017;82(5):495-508. doi:10.2298/JSC161220045B .
Božić, Aleksandra R., Filipovic, Nenad R., Novaković, Irena, Bjelogrlić, Snežana K., Nikolić, Jasmina B., Drmanić, Saša Ž., Marinković, Aleksandar D., "Synthesis, antioxidant and antimicrobial activity of carbohydrazones" in Journal of the Serbian Chemical Society, 82, no. 5 (2017):495-508, https://doi.org/10.2298/JSC161220045B . .