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Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties

Authorized Users Only
2017
Authors
Zdunić, Gordana
Gođevac, Dejan
Savikin, Katarina
Petrovic, Silvana
Article (Published version)
Metadata
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Abstract
A comparative analysis of the phenolic compounds in the 70% EtOH extracts of Hypericum acutum, H. androsaemum, H. barbatum, H hirsutum, H maculatum, and H richeri has been carried out using high-performance liquid chromatography coupled with photodiode array UV detection and high resolution TOF mass spectrometry. Quercetin, astilbin, I3,II8-biapigenin, orientin, 2"-O-acetylorientin, three phenolcarboxylic acids, and eight flavonols 3-O-glycosides were identified in the extracts on the basis of their on-line UV spectra, accurate mass spectral data, and in comparison of retention times with those from the standards. Fingerprint analysis of the extracts revealed significant differences in the qualitative and quantitative chemical composition of the studied species. Antioxidant assays with various reaction mechanisms were used including ferric reducing antioxidant power (FRAP) assay, DPPH, ABTS, superoxide anion radical scavenging capacity and inhibition of liposome peroxidation induced by... Fe2+. The most potent were extracts of H acutum and H maculatum indicating this Hypericum species interesting for further research aimed as a potentially new source of biologically active compounds.

Keywords:
Hypericum species / Chemical analysis / LC/MS / HPLC/DAD / Antioxidant activity
Source:
Natural Product Communications, 2017, 12, 11, 1805-1811
Publisher:
  • Natural Product Incorporation

DOI: 10.1177/1934578X1701201140

ISSN: 1934-578X

WoS: 000417552000039

Scopus: 2-s2.0-85035243200
[ Google Scholar ]
11
9
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/2118
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Zdunić, Gordana
AU  - Gođevac, Dejan
AU  - Savikin, Katarina
AU  - Petrovic, Silvana
PY  - 2017
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/2118
AB  - A comparative analysis of the phenolic compounds in the 70% EtOH extracts of Hypericum acutum, H. androsaemum, H. barbatum, H hirsutum, H maculatum, and H richeri has been carried out using high-performance liquid chromatography coupled with photodiode array UV detection and high resolution TOF mass spectrometry. Quercetin, astilbin, I3,II8-biapigenin, orientin, 2"-O-acetylorientin, three phenolcarboxylic acids, and eight flavonols 3-O-glycosides were identified in the extracts on the basis of their on-line UV spectra, accurate mass spectral data, and in comparison of retention times with those from the standards. Fingerprint analysis of the extracts revealed significant differences in the qualitative and quantitative chemical composition of the studied species. Antioxidant assays with various reaction mechanisms were used including ferric reducing antioxidant power (FRAP) assay, DPPH, ABTS, superoxide anion radical scavenging capacity and inhibition of liposome peroxidation induced by Fe2+. The most potent were extracts of H acutum and H maculatum indicating this Hypericum species interesting for further research aimed as a potentially new source of biologically active compounds.
PB  - Natural Product Incorporation
T2  - Natural Product Communications
T1  - Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties
VL  - 12
IS  - 11
SP  - 1805
EP  - 1811
DO  - 10.1177/1934578X1701201140
UR  - Conv_3834
ER  - 
@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Savikin, Katarina and Petrovic, Silvana",
year = "2017",
abstract = "A comparative analysis of the phenolic compounds in the 70% EtOH extracts of Hypericum acutum, H. androsaemum, H. barbatum, H hirsutum, H maculatum, and H richeri has been carried out using high-performance liquid chromatography coupled with photodiode array UV detection and high resolution TOF mass spectrometry. Quercetin, astilbin, I3,II8-biapigenin, orientin, 2"-O-acetylorientin, three phenolcarboxylic acids, and eight flavonols 3-O-glycosides were identified in the extracts on the basis of their on-line UV spectra, accurate mass spectral data, and in comparison of retention times with those from the standards. Fingerprint analysis of the extracts revealed significant differences in the qualitative and quantitative chemical composition of the studied species. Antioxidant assays with various reaction mechanisms were used including ferric reducing antioxidant power (FRAP) assay, DPPH, ABTS, superoxide anion radical scavenging capacity and inhibition of liposome peroxidation induced by Fe2+. The most potent were extracts of H acutum and H maculatum indicating this Hypericum species interesting for further research aimed as a potentially new source of biologically active compounds.",
publisher = "Natural Product Incorporation",
journal = "Natural Product Communications",
title = "Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties",
volume = "12",
number = "11",
pages = "1805-1811",
doi = "10.1177/1934578X1701201140",
url = "Conv_3834"
}
Zdunić, G., Gođevac, D., Savikin, K.,& Petrovic, S.. (2017). Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties. in Natural Product Communications
Natural Product Incorporation., 12(11), 1805-1811.
https://doi.org/10.1177/1934578X1701201140
Conv_3834
Zdunić G, Gođevac D, Savikin K, Petrovic S. Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties. in Natural Product Communications. 2017;12(11):1805-1811.
doi:10.1177/1934578X1701201140
Conv_3834 .
Zdunić, Gordana, Gođevac, Dejan, Savikin, Katarina, Petrovic, Silvana, "Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties" in Natural Product Communications, 12, no. 11 (2017):1805-1811,
https://doi.org/10.1177/1934578X1701201140 .,
Conv_3834 .

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