CER - Central Repository
Institute of Chemistry, Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   Central Repository
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
  •   Central Repository
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Interactions of Aromatic Residues in Amyloids: A Survey of Protein Data Bank Crystallographic Data

Authorized Users Only
2017
Authors
Stanković, Ivana
Bozinovski, Dragana M.
Brothers, Edward N.
Belić, Milivoj
Hall, Michael B.
Zarić, Snežana D.
Article (Published version)
Metadata
Show full item record
Abstract
Aromatic-aromatic interactions have long been considered important in the self assembly of amyloids. In spite of their importance, aromatic amino acids are not detected in every amyloid. In the present study, the occurrence and geometry of these interactions were analyzed for the amyloid structures found in the Protein Data Bank. The data confirm that aromatic amino acids are not crucial for amyloid fibril formation. In fact, aromatic-aliphatic interactions are more frequent than the aromatic-aromatic interactions. Aromatic-aliphatic interactions are present in higher numbers of structures and in certain amyloid sequences they are more frequent than aromatic-aromatic interactions. An analysis of aromatic/aromatic interactions shows different interaction geometries in intrasheet and intersheet contacts; the intrasheet aromatic-aromatic interactions are mostly parallel and displaced, while intersheet interactions are not parallel. Thus, among the aromatic-aromatic interactions there are ...important edge-to-face attractions in addition to parallel stacking ones.

Source:
Crystal Growth & Design, 2017, 17, 12, 6353-6362
Publisher:
  • Amer Chemical Soc, Washington
Projects:
  • Noncovalent interactions of pi-systems and their role in molecular recognition (RS-172065)
  • NPRP grant from Qatar National Research Fund (a member of the Qatar Foundation) [NPRP8-425-1-087]

DOI: 10.1021/acs.cgd.7b01035

ISSN: 1528-7483

WoS: 000417669900025

Scopus: 2-s2.0-85046349132
[ Google Scholar ]
8
8
URI
http://cer.ihtm.bg.ac.rs/handle/123456789/2115
Collections
  • Radovi istraživača / Researchers' publications
Institution
IHTM

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

OpenAIRERCUB