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dc.creatorMileski, Ksenija S.
dc.creatorTrifunović, Snežana
dc.creatorCiric, Ana D.
dc.creatorSakic, Zeljana M.
dc.creatorRistic, Mihailo S.
dc.creatorTodorović, Nina
dc.creatorMatevski, Vlado S.
dc.creatorMarin, Petar D.
dc.creatorTešević, Vele
dc.creatorDzamic, Ana M.
dc.date.accessioned2019-01-30T17:53:40Z
dc.date.available2019-01-30T17:53:40Z
dc.date.issued2017
dc.identifier.issn0021-8561
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/2110
dc.description.abstractThe essential oil, different extracts, and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%), and beta-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using an HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicating coumarins as the main constituents. In addition, new chromone (1) and six known furanocoumarins (2-7) were isolated from the roots and structurally elucidated by combined spectroscopic methods. The aerial part extracts exhibited higher polyphenolic contents and antioxidant activity evaluated by three radical scavenging assays. Using a microwell dilution method, the strongest antibacterial activity profiles were determined for ethanol and methanol root extracts (minimum bactericidal concentrations (MBCs) = 0.25-3.00 mg/mL), which were comparable to the activity of streptomycin (MBCs = 0.34-1.24 mg/mL), while the strongest antibacterial compound of A. pancicii was oxypeucedanin hydrate (MBCs = 0.50-8.00 mg/mL). Antifungal potential was in moderate extent, and the highest activity was obtained for root methanol extract (minimum fungicidal concentrations (MFCs) = 4.00-14.00 mg/mL). Tested sub-minimum inhibitory concentrations (subMICs) of the extracts and isolated compounds inhibited selected Pseudomonasaeruginosa PAO1 virulence determinants. The most reduced growth of P. aeruginosa colony was in the presence of isolated oxypeucedanin. Ethanol (17.36-46.98%) and methanol (34.54-52.43%) root extracts showed higher anti-biofilm activity compared to streptomycin (49.40-88.36%) and ampicillin (56.46-92.16%).en
dc.publisherAmerican Chemical Society (ACS)
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173029/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Agricultural and Food Chemistry
dc.subjectAngelica panciciien
dc.subjectchemical compositionen
dc.subjectcoumarinsen
dc.subjectessential oilen
dc.subjectantioxidanten
dc.subjectantimicrobialen
dc.subjectantiquorum sensing activityen
dc.titleResearch on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Rootsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилески, Ксенија С.; Ристиц, Михаило С.; Тодоровић, Нина; Цириц, Aна Д.; Сакиц, Зељана М.; Матевски, Владо С.; Дзамиц, Aна М.; Трифуновиц, Снезана С.; Марин, Петар Д.; Тесевиц, Веле В.;
dc.citation.volume65
dc.citation.issue50
dc.citation.spage10933
dc.citation.epage10949
dc.citation.other65(50): 10933-10949
dc.citation.rankaM21
dc.description.otherThe peer-reviewed version: [http://cer.ihtm.bg.ac.rs/handle/123456789/2936]
dc.identifier.pmid29129053
dc.identifier.doi10.1021/acs.jafc.7b04202
dc.identifier.rcubConv_3846
dc.identifier.scopus2-s2.0-85038626982
dc.identifier.wos000418783400013
dc.type.versionpublishedVersion


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