Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots
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2017
Authors
Mileski, Ksenija S.Trifunović, Snežana

Ciric, Ana D.
Sakic, Zeljana M.
Ristic, Mihailo S.
Todorović, Nina

Matevski, Vlado S.
Marin, Petar D.

Tešević, Vele

Dzamic, Ana M.
Article (Published version)

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The essential oil, different extracts, and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%), and beta-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using an HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicating coumarins as the main constituents. In addition, new chromone (1) and six known furanocoumarins (2-7) were isolated from the roots and structurally elucidated by combined spectroscopic methods. The aerial part extracts exhibited higher polyphenolic contents and antioxidant activity evaluated by three radical scavenging assays. Using a microwell dilution method, the strongest antibacterial activity profiles were determined for ethanol and methanol root extracts (m...inimum bactericidal concentrations (MBCs) = 0.25-3.00 mg/mL), which were comparable to the activity of streptomycin (MBCs = 0.34-1.24 mg/mL), while the strongest antibacterial compound of A. pancicii was oxypeucedanin hydrate (MBCs = 0.50-8.00 mg/mL). Antifungal potential was in moderate extent, and the highest activity was obtained for root methanol extract (minimum fungicidal concentrations (MFCs) = 4.00-14.00 mg/mL). Tested sub-minimum inhibitory concentrations (subMICs) of the extracts and isolated compounds inhibited selected Pseudomonasaeruginosa PAO1 virulence determinants. The most reduced growth of P. aeruginosa colony was in the presence of isolated oxypeucedanin. Ethanol (17.36-46.98%) and methanol (34.54-52.43%) root extracts showed higher anti-biofilm activity compared to streptomycin (49.40-88.36%) and ampicillin (56.46-92.16%).
Keywords:
Angelica pancicii / chemical composition / coumarins / essential oil / antioxidant / antimicrobial / antiquorum sensing activitySource:
Journal of Agricultural and Food Chemistry, 2017, 65, 50, 10933-10949Publisher:
- American Chemical Society (ACS)
Funding / projects:
- Micromorphological, phytochemical and molecular investigations of plants - systematic, ecological and applicative aspects (RS-173029)
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
Note:
- The peer-reviewed version: http://cer.ihtm.bg.ac.rs/handle/123456789/2936
DOI: 10.1021/acs.jafc.7b04202
ISSN: 0021-8561
PubMed: 29129053
WoS: 000418783400013
Scopus: 2-s2.0-85038626982
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IHTMTY - JOUR AU - Mileski, Ksenija S. AU - Trifunović, Snežana AU - Ciric, Ana D. AU - Sakic, Zeljana M. AU - Ristic, Mihailo S. AU - Todorović, Nina AU - Matevski, Vlado S. AU - Marin, Petar D. AU - Tešević, Vele AU - Dzamic, Ana M. PY - 2017 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2110 AB - The essential oil, different extracts, and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%), and beta-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using an HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicating coumarins as the main constituents. In addition, new chromone (1) and six known furanocoumarins (2-7) were isolated from the roots and structurally elucidated by combined spectroscopic methods. The aerial part extracts exhibited higher polyphenolic contents and antioxidant activity evaluated by three radical scavenging assays. Using a microwell dilution method, the strongest antibacterial activity profiles were determined for ethanol and methanol root extracts (minimum bactericidal concentrations (MBCs) = 0.25-3.00 mg/mL), which were comparable to the activity of streptomycin (MBCs = 0.34-1.24 mg/mL), while the strongest antibacterial compound of A. pancicii was oxypeucedanin hydrate (MBCs = 0.50-8.00 mg/mL). Antifungal potential was in moderate extent, and the highest activity was obtained for root methanol extract (minimum fungicidal concentrations (MFCs) = 4.00-14.00 mg/mL). Tested sub-minimum inhibitory concentrations (subMICs) of the extracts and isolated compounds inhibited selected Pseudomonasaeruginosa PAO1 virulence determinants. The most reduced growth of P. aeruginosa colony was in the presence of isolated oxypeucedanin. Ethanol (17.36-46.98%) and methanol (34.54-52.43%) root extracts showed higher anti-biofilm activity compared to streptomycin (49.40-88.36%) and ampicillin (56.46-92.16%). PB - American Chemical Society (ACS) T2 - Journal of Agricultural and Food Chemistry T1 - Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots VL - 65 IS - 50 SP - 10933 EP - 10949 DO - 10.1021/acs.jafc.7b04202 ER -
@article{ author = "Mileski, Ksenija S. and Trifunović, Snežana and Ciric, Ana D. and Sakic, Zeljana M. and Ristic, Mihailo S. and Todorović, Nina and Matevski, Vlado S. and Marin, Petar D. and Tešević, Vele and Dzamic, Ana M.", year = "2017", abstract = "The essential oil, different extracts, and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%), and beta-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using an HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicating coumarins as the main constituents. In addition, new chromone (1) and six known furanocoumarins (2-7) were isolated from the roots and structurally elucidated by combined spectroscopic methods. The aerial part extracts exhibited higher polyphenolic contents and antioxidant activity evaluated by three radical scavenging assays. Using a microwell dilution method, the strongest antibacterial activity profiles were determined for ethanol and methanol root extracts (minimum bactericidal concentrations (MBCs) = 0.25-3.00 mg/mL), which were comparable to the activity of streptomycin (MBCs = 0.34-1.24 mg/mL), while the strongest antibacterial compound of A. pancicii was oxypeucedanin hydrate (MBCs = 0.50-8.00 mg/mL). Antifungal potential was in moderate extent, and the highest activity was obtained for root methanol extract (minimum fungicidal concentrations (MFCs) = 4.00-14.00 mg/mL). Tested sub-minimum inhibitory concentrations (subMICs) of the extracts and isolated compounds inhibited selected Pseudomonasaeruginosa PAO1 virulence determinants. The most reduced growth of P. aeruginosa colony was in the presence of isolated oxypeucedanin. Ethanol (17.36-46.98%) and methanol (34.54-52.43%) root extracts showed higher anti-biofilm activity compared to streptomycin (49.40-88.36%) and ampicillin (56.46-92.16%).", publisher = "American Chemical Society (ACS)", journal = "Journal of Agricultural and Food Chemistry", title = "Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots", volume = "65", number = "50", pages = "10933-10949", doi = "10.1021/acs.jafc.7b04202" }
Mileski, K. S., Trifunović, S., Ciric, A. D., Sakic, Z. M., Ristic, M. S., Todorović, N., Matevski, V. S., Marin, P. D., Tešević, V.,& Dzamic, A. M.. (2017). Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots. in Journal of Agricultural and Food Chemistry American Chemical Society (ACS)., 65(50), 10933-10949. https://doi.org/10.1021/acs.jafc.7b04202
Mileski KS, Trifunović S, Ciric AD, Sakic ZM, Ristic MS, Todorović N, Matevski VS, Marin PD, Tešević V, Dzamic AM. Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots. in Journal of Agricultural and Food Chemistry. 2017;65(50):10933-10949. doi:10.1021/acs.jafc.7b04202 .
Mileski, Ksenija S., Trifunović, Snežana, Ciric, Ana D., Sakic, Zeljana M., Ristic, Mihailo S., Todorović, Nina, Matevski, Vlado S., Marin, Petar D., Tešević, Vele, Dzamic, Ana M., "Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots" in Journal of Agricultural and Food Chemistry, 65, no. 50 (2017):10933-10949, https://doi.org/10.1021/acs.jafc.7b04202 . .