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dc.creatorJanjusevic, Ljiljana
dc.creatorKaraman, Maja
dc.creatorSibul, Filip
dc.creatorTommonaro, Giuseppina
dc.creatorIodice, Carmine
dc.creatorJakovljević, Dragica
dc.creatorPejin, Boris
dc.date.accessioned2019-01-30T17:52:40Z
dc.date.available2019-01-30T17:52:40Z
dc.date.issued2017
dc.identifier.issn1475-6366
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/2062
dc.description.abstractThis study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.en
dc.publisherTaylor & Francis Group
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceJournal of Enzyme Inhibition and Medicinal Chemistry
dc.subjectAChE inhibitory activityen
dc.subjectAlzheimer's diseaseen
dc.subjectanti (OH)-O-center dot activityen
dc.subjectTrametes versicoloren
dc.subjectwater extracten
dc.titleThe lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agentsen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractСибул, Филип; Иодице, Цармине; Јаковљевић, Драгица; Караман, Маја; Јањусевиц, Љиљана; Пејин, Борис; Томмонаро, Гиусеппина;
dc.citation.volume32
dc.citation.issue1
dc.citation.spage355
dc.citation.epage362
dc.citation.other32(1): 355-362
dc.citation.rankaM21
dc.identifier.pmid28097907
dc.identifier.doi10.1080/14756366.2016.1252759
dc.identifier.rcubConv_3663
dc.identifier.fulltexthttps://cer.ihtm.bg.ac.rs//bitstream/id/8492/2060.pdf
dc.identifier.scopus2-s2.0-85015591411
dc.identifier.wos000392591100028
dc.type.versionpublishedVersion


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