The lignicolous fungus Trametes versicolor (L.) Lloyd (1920): a promising natural source of antiradical and AChE inhibitory agents
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This study aimed to determine antiradical (DPPH center dot and (OH)-O-center dot) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against (OH)-O-center dot (3.21 mu g/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 mu g/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually u...sed as drug-like compounds or food supplements in the treatment of Alzheimer's disease.
Keywords:AChE inhibitory activity / Alzheimer's disease / anti (OH)-O-center dot activity / Trametes versicolor / water extract
Source:Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32, 1, 355-362
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