The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7
AuthorsCiric, Jovan T
Konstantinović, Sandra S.
Ilić, Slavica B.
Savic, Dragisa S
Veljković, Vlada B.
Article (Published version)
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The effect of isatin derivatives as a nitrogen source on antibiotic (hexaene H-85 and azalomycine B) production by Streptomyces hygroscopicus CH-7 was studied. Isatin-3-hydrazone, 5-chloroisatin-3-hydrazone, isatin-3-tosylhydrazone, 5-chloroisatin-3-tosylhydrazone, isatin-3-(4-hidroxy) benzoilhydrazone and 5-chloroisatin-3-(4'-hidroxy) benzoylhydrazone were synthesized in a crude glycerol, obtained during the biodiesel production from edible sunflower oil. The highest concentration of Hexaene H-85 is achieved with 5-chloroisatin-3-hydrazone (197 mu g/cm(3)) in medium, while isatin-3-hydrazone has the greatest impact on azalomycine B production (72 mu g/cm(3)).
Keywords:isatin derivatives / Streptomyces hygroscopicus / hexaene H-85 / azalomycine
Source:Hemijska industrija, 2016, 70, 2, 123-128
- Association of Chemical Engineers of Serbia