A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-[(piperidin-4-yl)methyl] piperazine. Biological evaluation of the synthesized compounds was illustrated by seven compounds, of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl) piperidin-4-yl] methyl} piperazine had the highest affinity for the dopamine D-2 receptor. For all seven selected compounds, docking analysis was performed in order to establish their structure-to-activity relationship.
TY - JOUR
AU - Penjišević, Jelena
AU - Šukalović, Vladimir
AU - Andrić, Deana
AU - Roglić, Goran
AU - Novaković, Irena
AU - Šoškić, Vukić
AU - Kostić Rajačić, Slađana
PY - 2016
UR - http://cer.ihtm.bg.ac.rs/handle/123456789/2017
AB - A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-[(piperidin-4-yl)methyl] piperazine. Biological evaluation of the synthesized compounds was illustrated by seven compounds, of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl) piperidin-4-yl] methyl} piperazine had the highest affinity for the dopamine D-2 receptor. For all seven selected compounds, docking analysis was performed in order to establish their structure-to-activity relationship.
PB - Serbian Chemical Soc, Belgrade
T2 - Journal of the Serbian Chemical Society
T1 - Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines
VL - 81
IS - 4
SP - 347
EP - 356
DO - 10.2298/JSC151021097P
ER -
@article{
author = "Penjišević, Jelena and Šukalović, Vladimir and Andrić, Deana and Roglić, Goran and Novaković, Irena and Šoškić, Vukić and Kostić Rajačić, Slađana",
year = "2016",
url = "http://cer.ihtm.bg.ac.rs/handle/123456789/2017",
abstract = "A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-[(piperidin-4-yl)methyl] piperazine. Biological evaluation of the synthesized compounds was illustrated by seven compounds, of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl) piperidin-4-yl] methyl} piperazine had the highest affinity for the dopamine D-2 receptor. For all seven selected compounds, docking analysis was performed in order to establish their structure-to-activity relationship.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines",
volume = "81",
number = "4",
pages = "347-356",
doi = "10.2298/JSC151021097P"
}
Penjišević, J., Šukalović, V., Andrić, D., Roglić, G., Novaković, I., Šoškić, V.,& Kostić Rajačić, S. (2016). Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines.
Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 81(4), 347-356.
https://doi.org/10.2298/JSC151021097P
Penjišević J, Šukalović V, Andrić D, Roglić G, Novaković I, Šoškić V, Kostić Rajačić S. Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines. Journal of the Serbian Chemical Society. 2016;81(4):347-356
Penjišević Jelena, Šukalović Vladimir, Andrić Deana, Roglić Goran, Novaković Irena, Šoškić Vukić, Kostić Rajačić Slađana, "Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines" Journal of the Serbian Chemical Society, 81, no. 4 (2016):347-356,
https://doi.org/10.2298/JSC151021097P .
