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Revealing the story of an orphan drug: clofazimine speciation and solubilization as a function of pH
(International Association of Physical Chemists, 2023)
Since the introduction of combinatorial chemistry and high-throughput screening in drug
discovery in the early 1990s, the solubility of new chemical entities (NCE) decreased drastically
while their lipophilicities ...
Clofazimine acid-base solubilization: influence of small organic acids’ concentration
(International Association of Physical Chemists, 2023)
Methods for drug solubilization have become important part of modern drug discovery and
development due to increasing number of extremely insoluble drugs and drug candidates.
One of such methods is acid-base ...