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Nanocrystal dispersion of DK-I-56–1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: Formulation approach toward improved in vivo performance
(Elsevier, 2020)
DK-I-56–1 (7‑methoxy‑2-(4‑methoxy‑d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one), a recently developed deuterated pyrazoloquinolinone, has been recognized as a lead candidate for treatment of various neuropsychiatric ...
Solubility-pH profile of desipramine hydrochloride in saline phosphate buffer: Enhanced solubility due to drug-buffer aggregates
(Elsevier, 2019)
Although solubility-pH data for desipramine hydrochloride (DsHCl) have been reported previously, the aim of the present study was to critically examine the aqueous solubility-pH behavior of DsHCl in buffer-free and buffered ...
Non-toxic poly(vinyl alcohol)/clay composites as electrode material for detection of 4-chlorophenol and 4-nitrophenol
(Elsevier, 2019)
Development of new electrode materials is necessary for the fabrication of sensors with low detection limits, high sensitivity and broad concentration range. Beside analytical parameters, the ability to replace rare and ...
Fatigue endurance design of plates with two semicircular edge notches and one quarter-elliptical corner crack or through-the-thickness crack
(Elsevier, 2019)
This paper presents an investigation on the failure of plates with double-edge notches and fatigue damage. The
main aim is to develop a computational model for estimating the behaviour of a quarter-elliptical corner crack ...
Field Effect and Local Gating in Nitrogen‐Terminated Nanopores (NtNP) and Nanogaps (NtNG) in Graphene
(Wiley, 2021)
Functionalization of electrodes is a wide‐used strategy in various applications ranging from single‐molecule sensing and protein sequencing, to ion trapping, to desalination. We demonstrate, employing non‐equilibrium Green′s ...
Briggs-Rauscher reaction as a novel electrochemical detector for phosphate tungsten and phosphate molybdenum bronzes
(Elsevier, 2019)
Briggs-Rauscher (BR) oscillatory reaction is a chemical system very sensitive to different analyte addition. Changes in oscillatory dynamics, by analyte addition, could be successfully used for the determination of analyte ...
Dehydrogenative C(sp3)–H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions
(Royal Society of Chemistry (RSC), 2019)
The organocatalyzed Mannich reaction of unsubstituted and N-aryl-substituted tetrahydroisoquinolines (THIQs) and the Strecker reaction of several N-aryl-substituted THIQs through dehydrogenative C(sp3)–H bond functionalization ...
Rapid detection of olive oil blends using a paper-based portable microfluidic platform
(Elsevier, 2021)
This paper presents an application of a portable microfluidic platform based on a filter paper on which multi-walled carbon nanotubes were deposited to quickly determine the quality of olive oil by measuring electrical ...
Aerogel Re/Pd-TiO2/SiO2 and Co/Mo-Al2O3/SiO2 catalysts for hydrodesulphurisation of dibenzothiophene and 4,6-dimethyldibenzothiophene
(Elsevier, 2021)
Re/Pd-TiO2/SiO2 and Co/Mo-Al2O3/SiO2 aerogel catalysts were synthesized using sol-gel method and supercritical drying in excess solvent, and investigated in the hydrodesulphurisation (HDS) of dibenzothiophene (DBT) and ...
Controlling Pd-Catalyzed N-Arylation and Dimroth Rearrangement in the Synthesis of N,1-Diaryl-1H-tetrazol-5-amines
(American Chemical Society (ACS), 2021)
The Pd-catalyzed N-arylation method for the synthesis of eighteen N,1-diaryl-1H-tetrazol-5-amine derivatives is reported. By running the reactions at 35 °C, compounds were isolated as single isomers since the undesired ...