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dc.creatorAvramov Ivić, Milka
dc.creatorAntanasijevic, Jelena
dc.creatorTrišović, Nemanja
dc.creatorAntanasijevic, Davor
dc.creatorLović, Jelena
dc.creatorMijin, Dušan
dc.creatorPetrović, Slobodan D.
dc.date.accessioned2019-01-30T17:50:08Z
dc.date.available2019-01-30T17:50:08Z
dc.date.issued2016
dc.identifier.issn1452-3981
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/1941
dc.description.abstractThe electrochemical behavior of phenobarbital sodium (PBS), paracetamol (PCM) and their binary mixtures was investigated using cyclic voltammetry (CV) and square wave voltammetry (SWV) at a bare gold electrode in a 0.05 M bicarbonate solution. A calibration curve of PBS obtained by SWV had two linear ranges, from 1.0 to 3.0 mu M and from 5.0 to 35.0 mu M with a limit of quantification (LOQ) of 0.62 mu M and a limit of detection (LOD) of 0.19 mu M, while a calibration curve of PCM was determined within the range from 10.0 to 50.0 mu M with a LOQ of 8.53 mu M and a LOD of 2.56 mu M. Both drugs underwent oxidation by irreversible, diffusion controlled process. The SW voltammograms of the drug mixtures produced complex, overlapping profiles and a chemometric method was applied for their decomposition. Two different artificial neural network (ANN) architectures, namely back-propagation neural network (BPNN) and general regression neural network (GRNN) were employed for the simultaneous prediction of the concentrations of the drugs in a synthetic sample. The BPNN model had higher accuracy (mean absolute percentage error values were in the range of 3.6-8.4%) and thus it can be used for the simultaneous determination of PBS and PCM.en
dc.publisherEsg, Belgrade
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172060/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172007/RS//
dc.rightsopenAccess
dc.sourceInternational Journal of Electrochemical Science
dc.subjectphenobarbitalen
dc.subjectparacetamolen
dc.subjectvoltammetryen
dc.subjectchemometricsen
dc.titleA Chemometrical Analysis of Voltammetric Data for Simultaneous Determination of Phenobarbital Sodium and Paracetamol Obtained at a Gold Electrodeen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМијин, Дусан; Ловић, Јелена; Трисовиц, Немања П.; Aнтанасијевиц, Јелена; Aврамов Ивић, Милка; Aнтанасијевиц, Давор; Петровић, Слободан Д.;
dc.citation.volume11
dc.citation.issue7
dc.citation.spage5935
dc.citation.epage5951
dc.citation.other11(7): 5935-5951
dc.citation.rankM23
dc.identifier.doi10.20964/2016.07.48
dc.identifier.rcubConv_3602
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/8372/1939.pdf
dc.identifier.scopus2-s2.0-84978138152
dc.identifier.wos000384905600050
dc.type.versionpublishedVersion


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